A Mathematical Method of Estimating the Production of Red Blood Cells by Repeated Injections of Radioactivity
Evaluation of erythropoietic function by the use of radioactive labels is discussed in relation to the capturerecapture method for investigating changes in wild animal populations. Mathematical equations are derived and applied to experimental data. It is shown how estimates of the rate of creation at isolated instants may be made without actually fitting the differential equation for population growth, and without assuming the form of the mortality function of the cells. The methods proposed are based on the comparison of the value and gradient of radioactivity of samples of cells immediately before and after a number (possibly one) of successive injections, and minimize the number of injections necessary. (H.H.D.)
- Research Organization:
- Univ. of Melbourne
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-032695
- OSTI ID:
- 4781531
- Journal Information:
- Biometrics, Vol. 18, Issue 2; Other Information: Orig. Receipt Date: 31-DEC-62; ISSN 0006-341X
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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