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Title: RADIOACTIVE METAL MOBILIZATION

Abstract

The potentialities, drawbacks, and limitations of ethylenediaminetetraacetic acid (EDTA) in the removal of radioaetive metals are discussed. The biological effectiveness of EDTA is compared with that of several other chelating agents, with emphasis on CaNa/sub 3/-diethylene- triaminepentaacetic acid (DTPA). Data are tabulated on the effect of DTAA and EDTA on the retention of Y/sup 91/, Ce/sup 144/, Th/sup 234/, Pu/sup 23 and Am/ sup 241/ in rats. Data are also tabulated on the effects of EDTA, DTPA, hydroxyethylenediaminetriacetic acid (HEDTA), and 1-2,- diaminecyclohexanetetraacetic acid (CDTA) on the retention of Ce/sup 144/ in the organs of rats, the effects of Na polyphosphate (Graham's salt) on the retention of Y/sup 91/, Ce/sup 144/, and Pusup 239/ in the liver, kidneys, and skeleton of rats. The effects of certain esterified polyamino acids are discussed and data are presented on the effects N - (2-hydroxyethyl)ethylenediamine-N,-N,N - triacetic acid (HEDTA) and derivative and N',N -bis(2- hydroxycyclohexyl)ethylenediamine-N,N -diacetic acid (DOC) administered as calcium sodium chelate (Ch) or respective ester lactone (E), on the distribution of Ce/sup 144/ and Y/sup 91/ in the organs of the rat. The effects of individual chelating agents on the removal of Sr/up 89/ and Sr/sup 90/ are also reviewed. Reaetion mechanismsmore » involved and the effects of dose, time of administration, and chemical composition on the biological effectiveness of a number of chelating agents are discussed. It is concluded that DTPA is one of the more effective chelating agents. (C.H.)« less

Authors:
Publication Date:
Research Org.:
Inst. of Radiobiology, Karlsruhe, Ger.
OSTI Identifier:
4777710
Report Number(s):
KFK-76
NSA Number:
NSA-16-029327
Resource Type:
Journal Article
Journal Name:
Federation Proc.
Additional Journal Information:
Journal Volume: Vol: 20: Suppl. No. 10; Other Information: KFK-76. Orig. Receipt Date: 31-DEC-62
Country of Publication:
Germany
Language:
English
Subject:
METALS, CERAMICS, AND OTHER MATERIALS; AMERICIUM 241; AMINES; BIOLOGY; BONES; CERIUM 144; CHELATES; COMPLEXES; EDTA; EFFICIENCY; ESTERS; KIDNEYS; LIVER; ORGANIC ACIDS; PLUTONIUM 239; QUALITATIVE ANALYSIS; RADIATION DOSES; RADIOBIOLOGY; RATS; REACTION KINETICS; SODIUM PHOSPHATES; STRONTIUM 89; STRONTIUM 90; THORIUM 234; YTTRIUM 91

Citation Formats

Catsch, A. RADIOACTIVE METAL MOBILIZATION. Germany: N. p., 1961. Web.
Catsch, A. RADIOACTIVE METAL MOBILIZATION. Germany.
Catsch, A. 1961. "RADIOACTIVE METAL MOBILIZATION". Germany.
@article{osti_4777710,
title = {RADIOACTIVE METAL MOBILIZATION},
author = {Catsch, A},
abstractNote = {The potentialities, drawbacks, and limitations of ethylenediaminetetraacetic acid (EDTA) in the removal of radioaetive metals are discussed. The biological effectiveness of EDTA is compared with that of several other chelating agents, with emphasis on CaNa/sub 3/-diethylene- triaminepentaacetic acid (DTPA). Data are tabulated on the effect of DTAA and EDTA on the retention of Y/sup 91/, Ce/sup 144/, Th/sup 234/, Pu/sup 23 and Am/ sup 241/ in rats. Data are also tabulated on the effects of EDTA, DTPA, hydroxyethylenediaminetriacetic acid (HEDTA), and 1-2,- diaminecyclohexanetetraacetic acid (CDTA) on the retention of Ce/sup 144/ in the organs of rats, the effects of Na polyphosphate (Graham's salt) on the retention of Y/sup 91/, Ce/sup 144/, and Pusup 239/ in the liver, kidneys, and skeleton of rats. The effects of certain esterified polyamino acids are discussed and data are presented on the effects N - (2-hydroxyethyl)ethylenediamine-N,-N,N - triacetic acid (HEDTA) and derivative and N',N -bis(2- hydroxycyclohexyl)ethylenediamine-N,N -diacetic acid (DOC) administered as calcium sodium chelate (Ch) or respective ester lactone (E), on the distribution of Ce/sup 144/ and Y/sup 91/ in the organs of the rat. The effects of individual chelating agents on the removal of Sr/up 89/ and Sr/sup 90/ are also reviewed. Reaetion mechanisms involved and the effects of dose, time of administration, and chemical composition on the biological effectiveness of a number of chelating agents are discussed. It is concluded that DTPA is one of the more effective chelating agents. (C.H.)},
doi = {},
url = {https://www.osti.gov/biblio/4777710}, journal = {Federation Proc.},
number = ,
volume = Vol: 20: Suppl. No. 10,
place = {Germany},
year = {Fri Sep 01 00:00:00 EDT 1961},
month = {Fri Sep 01 00:00:00 EDT 1961}
}