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Title: Immunological memory is associative

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Abstract

The purpose of this paper is to show that immunological memory is an associative and robust memory that belongs to the class of sparse distributed memories. This class of memories derives its associative and robust nature by sparsely sampling the input space and distributing the data among many independent agents. Other members of this class include a model of the cerebellar cortex and Sparse Distributed Memory (SDM). First we present a simplified account of the immune response and immunological memory. Next we present SDM, and then we show the correlations between immunological memory and SDM. Finally, we show how associative recall in the immune response can be both beneficial and detrimental to the fitness of an individual.

Authors:
;  [1];  [2]
  1. New Mexico Univ., Albuquerque, NM (United States). Dept. of Computer Science
  2. Los Alamos National Lab., NM (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States); Sullivan Foundation (Joseph P. and Jeanne M.) (United States); Office of Naval Research, Washington, DC (United States); National Science Foundation, Washington, DC (United States); Santa Fe Inst., NM (United States)
OSTI Identifier:
477660
Report Number(s):
LA-UR-96-3891; CONF-961248-1
ON: DE97002367; CNN: NIH AI28433, RR06555;ONR N00014-95-1-0364;NSF IRI-9157644
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Conference
Resource Relation:
Conference: ICMAS `96: Multiagent systems workshop on imunity-based systems, Kyoto (Japan), Dec 1996; Other Information: PBD: [1996]
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RETICULOENDOTHELIAL SYSTEM; MATHEMATICAL MODELS; ANTIBODIES; LYMPHOCYTES

Citation Formats

Smith, D J, Forrest, S, and Perelson, A S. Immunological memory is associative. United States: N. p., 1996. Web.
Smith, D J, Forrest, S, & Perelson, A S. Immunological memory is associative. United States.
Smith, D J, Forrest, S, and Perelson, A S. 1996. "Immunological memory is associative". United States. https://www.osti.gov/servlets/purl/477660.
@article{osti_477660,
title = {Immunological memory is associative},
author = {Smith, D J and Forrest, S and Perelson, A S},
abstractNote = {The purpose of this paper is to show that immunological memory is an associative and robust memory that belongs to the class of sparse distributed memories. This class of memories derives its associative and robust nature by sparsely sampling the input space and distributing the data among many independent agents. Other members of this class include a model of the cerebellar cortex and Sparse Distributed Memory (SDM). First we present a simplified account of the immune response and immunological memory. Next we present SDM, and then we show the correlations between immunological memory and SDM. Finally, we show how associative recall in the immune response can be both beneficial and detrimental to the fitness of an individual.},
doi = {},
url = {https://www.osti.gov/biblio/477660}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 31 00:00:00 EST 1996},
month = {Tue Dec 31 00:00:00 EST 1996}
}

Conference:
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