The role of the laboratory mouse in the human genome project
- Univ. of Michigan School of Medicine, Ann Arbor, MI (United States)
The long-term goal of the human genome project is to identify and establish the function of each of the estimated 100,000 genes in the genome. The gene-discovery phase of the project is proceeding rapidly, via large-scale sequencing of genomic and cDNA clones. Establishing the functional roles for these genes is the challenge for the future. New methods have improved the power of the laboratory mouse to address questions of gene function and have attracted many investigators to the field. There has been dramatic progress in the efficiency of positional cloning of mutant mouse genes, induction of new mutants by chemical mutagenesis, targeted mutation of cloned genes by homologous recombination, strategies for analysis of polygenic traits, and comparative mapping of the human and mouse chromosomes. The contents of recent issues of the journals Human Molecular Genetics, Nature Genetics, and Genomics demonstrate the striking extent to which mouse genes and mouse mutants now occupy the attention of human geneticists. This paper provides a brief survey of recent developments with particular relevance to human genetics and the analysis of gene function. 56 refs., 2 figs., 4 tabs.
- DOE Contract Number:
- FG02-95ER62050
- OSTI ID:
- 476746
- Journal Information:
- American Journal of Human Genetics, Vol. 59, Issue 4; Other Information: PBD: Oct 1996
- Country of Publication:
- United States
- Language:
- English
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