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Title: A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates

Abstract

The effect of hypothyroidism induced by intravenous injections of I 131 on antibody production, the anamnestic response, and on antibody decay rate, compared to normal animals, was studied in 63 rabbits. After initial antigenic stimulation, normal animals reached a higher peak titer on an average of 5 days earlier than hypothyroid animals. Antibody half-life in these animals, as measured by time for antibody concentration to fall 50% from peak titer, was 11.4 days in normal compared to 21.3 days in hypothyroid animals. Following a second antigenic stimulation, normal rabbits reached a peak titer in an average of 6.4 days compared to 15 days for hypothyroid animals. The half-life for both groups was measured by determining the rate of disappearance of passively infused antibody. The half-life, thus measured, in normals was 2.4 plus or minus 0.2 days and was 8.8 plus or minus 1.9 days for hypothyroid animals. The time required for serum-tissue equilibration of infused antibody in normals was 1.0 plus or minus 0.00 days compared to 2.3 plus or minus 1.5 days in hypothyroid animals.

Authors:
; ;
Publication Date:
Research Org.:
Originating Research Org. not identified
Sponsoring Org.:
USDOE
OSTI Identifier:
4764433
NSA Number:
NSA-16-031407
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Allergy; Journal Volume: 33; Journal Issue: 1; Other Information: Orig. Receipt Date: 31-DEC-62
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; ANTIGENS; BLOOD SERUM; DISEASES; HYPOTHYROIDISM; IMMUNITY; IODINE 131; RABBITS; THYROID; TISSUES

Citation Formats

Johnstone, Douglas E., Howland, Joe W., and Michaelson, Solomon. A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates. Country unknown/Code not available: N. p., 1962. Web. doi:10.1016/0021-8707(62)90057-6.
Johnstone, Douglas E., Howland, Joe W., & Michaelson, Solomon. A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates. Country unknown/Code not available. doi:10.1016/0021-8707(62)90057-6.
Johnstone, Douglas E., Howland, Joe W., and Michaelson, Solomon. Mon . "A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates". Country unknown/Code not available. doi:10.1016/0021-8707(62)90057-6.
@article{osti_4764433,
title = {A study of the influence of experimentally induced hypothyroidism on antibody production and decay rates},
author = {Johnstone, Douglas E. and Howland, Joe W. and Michaelson, Solomon},
abstractNote = {The effect of hypothyroidism induced by intravenous injections of I131 on antibody production, the anamnestic response, and on antibody decay rate, compared to normal animals, was studied in 63 rabbits. After initial antigenic stimulation, normal animals reached a higher peak titer on an average of 5 days earlier than hypothyroid animals. Antibody half-life in these animals, as measured by time for antibody concentration to fall 50% from peak titer, was 11.4 days in normal compared to 21.3 days in hypothyroid animals. Following a second antigenic stimulation, normal rabbits reached a peak titer in an average of 6.4 days compared to 15 days for hypothyroid animals. The half-life for both groups was measured by determining the rate of disappearance of passively infused antibody. The half-life, thus measured, in normals was 2.4 plus or minus 0.2 days and was 8.8 plus or minus 1.9 days for hypothyroid animals. The time required for serum-tissue equilibration of infused antibody in normals was 1.0 plus or minus 0.00 days compared to 2.3 plus or minus 1.5 days in hypothyroid animals.},
doi = {10.1016/0021-8707(62)90057-6},
journal = {Journal of Allergy},
number = 1,
volume = 33,
place = {Country unknown/Code not available},
year = {Mon Jan 01 00:00:00 EST 1962},
month = {Mon Jan 01 00:00:00 EST 1962}
}