EXPERIMENTAL DATA ON THE EARLY RADIATION REACTION OF THE DIGESTIVE SYSTEM. II. CHANGES IN THE MICROMOTILITY OF THE SMALL INTESTINE IN ANIMAL EXPERIMENTS AS A RESULT OF GENERAL OR ABDOMINAL RADIATION EXPOSURE

Journal Article · Mon Oct 01 00:00:00 EDT 1962 · Honvedorvos (Hungary)

OSTI ID:4755758

Santha, A

Micromotility stops within a few hours after general or abdominal irradiation with doses of 200 to 800 r as shown in dogs. The stoppage is preceded by a transient stimulation, which may be avoided by antihistamine and ganglioninhibitor treatment. Motility changes may be produced also in unirradiated dogs with crossed carotis circulation, explicable in terms of a transfer of so-called radiotoxins. If 0.1N HCl is introduced into the duodenum of the starved and irradiated donor animal, this will revive the micromotility of both donor and acceptor within 16 to 24 hours of t of both donor and acceptor within 16 to 24 hours of the irradiation even if complete paralysis had been produced. Up to 40 hr, the revival may be produced only in the acceptor animal. The ability to respond to hormonal stimulation disappears sooner in the animal suffering direct radiation damage. The clinical significance of the paralysis of micromotility is discussed in relation to early stages of radiation sickness. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-015683
• OSTI ID: 4755758
• Journal Information: Honvedorvos (Hungary), Vol. Vol: 14; Other Information: Orig. Receipt Date: 31-DEC-63
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ANTIHISTAMINICS
BLOOD CIRCULATION
BLOOD VESSELS
BODY
DISTRIBUTION
DOGS
DRUGS
FOOD
HORMONES
HYDROCHLORIC ACID
INTESTINE
MEDICINE
MUSCLES
NERVOUS SYSTEM
PARABIOSIS
PHYSIOLOGY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RADIOTOXINS
RECOVERY
SURGERY
TISSUES
TOXICITY
VARIATIONS