ACTION OF STRONTIUM IONS ON THE ISOLATED HEART OF THE RAT AND GUINEA PIG
Abstract
Addition of 2.1 mM/l Sr/sup ++/ (as SrCl/sub 2/) to the saline solution bathing rat heart progressively lowers the amplitude of contraction, to approximates 15% below normal within 10 min. This inhibition is preceded by a slight, transient stimulation of contraction. Inhibition is reversible if Sr/sup ++/ is removed within 4 to 5 min. In guinea pig heart under the same conditions, Sr/sup ++/ produces greater inhibition; amplitude is reduced 30% after 6 min., without a preliminary positive inotropic effect. If 90% of the Ca/sup ++/ ions in the salt solution are replaced by Sr/sup ++/, Sr/sup ++/ completely compensates for the lowering of Ca/sup ++/ concentration, indicating that it is completely equivalent to Ca in promoting contractility of rat heart muscle. However, in guinea pig heart the tonotropic action of Sr/sup ++/ was proportionally greater than that of Ca/sup ++/. Thus, at low Ca concentrations rat heart is more sensitive to Sr/sup ++/ than guinea pig heart. In the absence of Ca/sup ++/, Sr/sup ++/ stimulntes contraction to such an extent in both species that the excessive tonus practically abolishes heart action. It appears that Sr/sup ++/ cannot totally replace Ca/sup ++/ in the cardiac contractile mechanism. (H.H.D.)
- Authors:
- Publication Date:
- Research Org.:
- Faculte des Sciences, Paris
- OSTI Identifier:
- 4751641
- NSA Number:
- NSA-17-005686
- Resource Type:
- Journal Article
- Journal Name:
- Compt. Rend. Soc. Biol.
- Additional Journal Information:
- Journal Volume: Vol: 155; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
- Subject:
- BIOLOGY AND MEDICINE; CALCIUM; GUINEA PIGS; HEART; IONS; PHYSIOLOGY; RATS; STRONTIUM CHLORIDES
Citation Formats
Coraboueuf, E, Guilbault, P, Breton, D, and Dumont, M. ACTION OF STRONTIUM IONS ON THE ISOLATED HEART OF THE RAT AND GUINEA PIG. Country unknown/Code not available: N. p., 1961.
Web.
Coraboueuf, E, Guilbault, P, Breton, D, & Dumont, M. ACTION OF STRONTIUM IONS ON THE ISOLATED HEART OF THE RAT AND GUINEA PIG. Country unknown/Code not available.
Coraboueuf, E, Guilbault, P, Breton, D, and Dumont, M. 1961.
"ACTION OF STRONTIUM IONS ON THE ISOLATED HEART OF THE RAT AND GUINEA PIG". Country unknown/Code not available.
@article{osti_4751641,
title = {ACTION OF STRONTIUM IONS ON THE ISOLATED HEART OF THE RAT AND GUINEA PIG},
author = {Coraboueuf, E and Guilbault, P and Breton, D and Dumont, M},
abstractNote = {Addition of 2.1 mM/l Sr/sup ++/ (as SrCl/sub 2/) to the saline solution bathing rat heart progressively lowers the amplitude of contraction, to approximates 15% below normal within 10 min. This inhibition is preceded by a slight, transient stimulation of contraction. Inhibition is reversible if Sr/sup ++/ is removed within 4 to 5 min. In guinea pig heart under the same conditions, Sr/sup ++/ produces greater inhibition; amplitude is reduced 30% after 6 min., without a preliminary positive inotropic effect. If 90% of the Ca/sup ++/ ions in the salt solution are replaced by Sr/sup ++/, Sr/sup ++/ completely compensates for the lowering of Ca/sup ++/ concentration, indicating that it is completely equivalent to Ca in promoting contractility of rat heart muscle. However, in guinea pig heart the tonotropic action of Sr/sup ++/ was proportionally greater than that of Ca/sup ++/. Thus, at low Ca concentrations rat heart is more sensitive to Sr/sup ++/ than guinea pig heart. In the absence of Ca/sup ++/, Sr/sup ++/ stimulntes contraction to such an extent in both species that the excessive tonus practically abolishes heart action. It appears that Sr/sup ++/ cannot totally replace Ca/sup ++/ in the cardiac contractile mechanism. (H.H.D.)},
doi = {},
url = {https://www.osti.gov/biblio/4751641},
journal = {Compt. Rend. Soc. Biol.},
number = ,
volume = Vol: 155,
place = {Country unknown/Code not available},
year = {Mon Dec 18 00:00:00 EST 1961},
month = {Mon Dec 18 00:00:00 EST 1961}
}