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Title: Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs

Abstract

Guinea pigs were given whole-body Co 60 irradiation (650 r) and injected daily thereafter with cell-free extracts of homologous and heterologous spleen. Spleen of irradiated control guinea pigs showed a progressive reduction of alkaline phosphatase staining commencing after the 3rd postirradiation day and reaching a maximum on or about the 9th day. Treatment of the animals with spleen extracts modified the radioinduced changes in alkaline phosphatase staining, so that an almost normal appearance was noted over the entire 14-day observation period. Most of the alkaiine phosphatase-staining spleen elements were mature neutrophils. It was concluded that spleen extract treatment affects apparently various celluiar elements of spleen in a different way. The results support the hypothesis that protection of phosphorylization processes against effects of irradiation represent one of the mechanisms by which the radiation protective effect of spleen extracts is effected.

Authors:
;
Publication Date:
Research Org.:
Naval Medical Research Inst., Bethesda, Md.
Sponsoring Org.:
USDOE
OSTI Identifier:
4737818
NSA Number:
NSA-17-010370
Resource Type:
Journal Article
Journal Name:
Acta Haematologica
Additional Journal Information:
Journal Volume: 26; Journal Issue: 5; Other Information: Orig. Receipt Date: 31-DEC-63; Journal ID: ISSN 0001-5792
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL CELLS; BIOCHEMISTRY; BODY; ENZYMES; GAMMA RADIATION; GUINEA PIGS; LEUCOCYTES; NEUTROPHILS; PHOSPHATASES; RADIATION DOSES; RADIATION EFFECTS; RADIATION PROTECTION; RECOVERY; SPLEEN

Citation Formats

Ellinger, Friedrigh, and Strike, Thomas A. Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs. Country unknown/Code not available: N. p., 2004. Web. doi:10.1159/000206667.
Ellinger, Friedrigh, & Strike, Thomas A. Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs. Country unknown/Code not available. doi:10.1159/000206667.
Ellinger, Friedrigh, and Strike, Thomas A. Thu . "Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs". Country unknown/Code not available. doi:10.1159/000206667.
@article{osti_4737818,
title = {Effects of Cell-Free Spleen Extract Treatment on the Hematopoietic Tissues of Irradiated Guinea-Pigs},
author = {Ellinger, Friedrigh and Strike, Thomas A.},
abstractNote = {Guinea pigs were given whole-body Co60 irradiation (650 r) and injected daily thereafter with cell-free extracts of homologous and heterologous spleen. Spleen of irradiated control guinea pigs showed a progressive reduction of alkaline phosphatase staining commencing after the 3rd postirradiation day and reaching a maximum on or about the 9th day. Treatment of the animals with spleen extracts modified the radioinduced changes in alkaline phosphatase staining, so that an almost normal appearance was noted over the entire 14-day observation period. Most of the alkaiine phosphatase-staining spleen elements were mature neutrophils. It was concluded that spleen extract treatment affects apparently various celluiar elements of spleen in a different way. The results support the hypothesis that protection of phosphorylization processes against effects of irradiation represent one of the mechanisms by which the radiation protective effect of spleen extracts is effected.},
doi = {10.1159/000206667},
journal = {Acta Haematologica},
issn = {0001-5792},
number = 5,
volume = 26,
place = {Country unknown/Code not available},
year = {2004},
month = {7}
}