Antibody Responses after Injection of Aqueous and Emulsified Influenza Virus Vaccines in Mice Chronically Exposed to Gamma Rays
Hemagglutination-inhibiting (HI) antibody levels induced by aqueous and emulsified influenza virus vaccines (PR8 strain) were compared in mice continuously exposed to gamma -rays. Irradiation was begun either 1 day or 8 months before vaccination and was continued until the animals were sacrificed. In mice first exposed to gamma -rays 1 day before vaccination, emulsified vaccine induced signigicantly higher HI levels at 21 and 42 days than those obtained after injection of aqueous vaccine. In mice first exposed to gamma rays 8 months before vaccination, emulsified vaccine induced slightly better responses than those obtained with aqueous vaccine even though the long period of prevaccination irradiation markedly inhibited antibody production. Chronic administration of mercaptoethylamine by an oral route did not protect antibody- forming tissues against chronic gamma -irradiation.
- Research Organization:
- Univ. of Michigan, Ann Arbor
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-023165
- OSTI ID:
- 4725795
- Journal Information:
- Radiation Research, Vol. 18, Issue 2; Other Information: Orig. Receipt Date: 31-DEC-63; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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