ESTIMATION OF FAT ABSORPTION BY MONITORING OF EXPIRED RADIOACTIVE CARBON DIOXIDE AFTER FEEDING A RADIOACTIVE FAT
A rapid, quantitative method based upon the oxidative decarboxylation of an easily, absorbable, short-chain fatty acid is described. The method for diagnosis of steatorrhea is based upon oral administration of radioactive glyceryl trioctanoate (RATO) and study of its oxidative decarboxylation as determined by monitoring expired C/sup 14/O/sub 2/. Results on 20 controls and 21 patients with steatorrhea of various types clearly separated 15 of the controls from all of the patients with steatorrhea, and 14 of 21 patients with steatorrhea fell below the lowest value encountered in 20 control subjects. The test was performed in the fasting patient, who was given a gelatin capsule containing 2 to 3 C of RATO in a corn oil base, and after 10 min C/sup 14/O/ sub 2/ in the expired air was measured. By calibration against standard sources the C/sup 14/O/sub 2/ is expressed in microcuries of activity. The average delay time is 26 min with a range of 8 to 54 min. The method thus provides a simple indication that gastric emptying has begun. (TCO)
- Research Organization:
- Univ. of California, Los Angeles
- NSA Number:
- NSA-17-021434
- OSTI ID:
- 4719088
- Journal Information:
- Gastroenterology (U.S.), Vol. Vol: 42; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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