skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS

Abstract

Transplantation immunity was successfully transferred to rabbits by sensitized lymphoid cells enclosed in Millipore chambers in x-irradiated and nonirradiated recipients. The chambers allowed antibody to diffuse from the cells contained therein. In nonirradiated rabbits graft rejection time was reduced by 2.8 days, Irradiation of rabbits with 400 or 800 r significantly reduced the rejection time. A dose of 400 r whole-body radiation in rabbits depressed only the immune response mediated by humoral antibodies, while the delayed form of hypersensitivity to the same antigen remained unaltered. On the other hand, 800 r depressed both forms of the immune response. The data suggest that the effect of radiation on skin homografts in the rabbit is due to the suppression of humoral antibodies, since doubling the dose of x rays with the consequent blocking of deiayed hypersensitivity had no further influence on the average time of homograft survival. The fact that passive transfer of transplantation immunity, by means of sensitized lymphoid cells enclosed within diffusion chambers, was accomplished in nonradiated and radiated rabbits indicates that humoral antibodies play an important role in rejection of siun homografts in the rabbit. (H.H.D.)

Authors:
;
Publication Date:
Research Org.:
Univ. Nacional Autonoma de Mexico, Mexico City
OSTI Identifier:
4711983
NSA Number:
NSA-17-010425
Resource Type:
Journal Article
Journal Name:
J. Exptl. Med.
Additional Journal Information:
Journal Volume: Vol: 116; Other Information: Orig. Receipt Date: 31-DEC-63
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; ANIMAL CELLS; ANTIBODIES; ANTIGENS; CYTOLOGY; IMMUNITY; LYMPH SYSTEM; LYMPHOID CELLS; RABBITS; RADIATION DOSES; SENSITIVITY; SKIN; TRANSPLANTS; X RADIATION

Citation Formats

Kretschmer, R R, and Perez-Tamayo, R. THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS. Country unknown/Code not available: N. p., 1962. Web. doi:10.1084/jem.116.6.879.
Kretschmer, R R, & Perez-Tamayo, R. THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS. Country unknown/Code not available. https://doi.org/10.1084/jem.116.6.879
Kretschmer, R R, and Perez-Tamayo, R. 1962. "THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS". Country unknown/Code not available. https://doi.org/10.1084/jem.116.6.879.
@article{osti_4711983,
title = {THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS},
author = {Kretschmer, R R and Perez-Tamayo, R},
abstractNote = {Transplantation immunity was successfully transferred to rabbits by sensitized lymphoid cells enclosed in Millipore chambers in x-irradiated and nonirradiated recipients. The chambers allowed antibody to diffuse from the cells contained therein. In nonirradiated rabbits graft rejection time was reduced by 2.8 days, Irradiation of rabbits with 400 or 800 r significantly reduced the rejection time. A dose of 400 r whole-body radiation in rabbits depressed only the immune response mediated by humoral antibodies, while the delayed form of hypersensitivity to the same antigen remained unaltered. On the other hand, 800 r depressed both forms of the immune response. The data suggest that the effect of radiation on skin homografts in the rabbit is due to the suppression of humoral antibodies, since doubling the dose of x rays with the consequent blocking of deiayed hypersensitivity had no further influence on the average time of homograft survival. The fact that passive transfer of transplantation immunity, by means of sensitized lymphoid cells enclosed within diffusion chambers, was accomplished in nonradiated and radiated rabbits indicates that humoral antibodies play an important role in rejection of siun homografts in the rabbit. (H.H.D.)},
doi = {10.1084/jem.116.6.879},
url = {https://www.osti.gov/biblio/4711983}, journal = {J. Exptl. Med.},
number = ,
volume = Vol: 116,
place = {Country unknown/Code not available},
year = {Sat Dec 01 00:00:00 EST 1962},
month = {Sat Dec 01 00:00:00 EST 1962}
}