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Title: Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis

Abstract

By a combination of balance and isotope techniques, the following parameters of Ca metabolism were measured: pool size, rate of loss from pool, urinary excretion, fecal excretion, intake, endogenous fecal Ca, absorption, balance, bone formation, and bone resorption. The subjects were two normal women and five women with postmenopausal osteoporosis, aged 41 to 74 years, and four patients with scoliosis, aged 12 to 22 years. The latter were studied before, shortly after, and many months after immobilization in plaster casts. On the basis of observed relationships, it appeared that the negative Ca balance observed in the older women was due to the low intensity of the various vectors of Ca metabolism, without clearcut distinction between the subjects with and without osteoporosis. Conversely, in the young patients with scoliosis, the negative balance incident to treatment by immobilization was associated with vectors of relatively high intensity whose relationships were altered temporarily.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Hospital for Special Surgery; and Cornell Univ., New York
Sponsoring Org.:
USDOE
OSTI Identifier:
4701844
NSA Number:
NSA-17-024863
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Clinical Investigation; Journal Volume: 42; Journal Issue: 6; Other Information: Orig. Receipt Date: 31-DEC-63
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; AGE; BONES; CALCIUM; DISEASES; MAN; MEDICINE; MENOPAUSE; METABOLISM; OSTEOPOROSIS; QUANTITATIVE ANALYSIS; RADIATION INJURIES; SEX

Citation Formats

Bronner, F., Richelle, L. J., Saville, P. D., Nicholas, J. A., and Cobb, J. R. Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis. Country unknown/Code not available: N. p., 1963. Web. doi:10.1172/JCI104782.
Bronner, F., Richelle, L. J., Saville, P. D., Nicholas, J. A., & Cobb, J. R. Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis. Country unknown/Code not available. doi:10.1172/JCI104782.
Bronner, F., Richelle, L. J., Saville, P. D., Nicholas, J. A., and Cobb, J. R. Sat . "Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis". Country unknown/Code not available. doi:10.1172/JCI104782.
@article{osti_4701844,
title = {Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis},
author = {Bronner, F. and Richelle, L. J. and Saville, P. D. and Nicholas, J. A. and Cobb, J. R.},
abstractNote = {By a combination of balance and isotope techniques, the following parameters of Ca metabolism were measured: pool size, rate of loss from pool, urinary excretion, fecal excretion, intake, endogenous fecal Ca, absorption, balance, bone formation, and bone resorption. The subjects were two normal women and five women with postmenopausal osteoporosis, aged 41 to 74 years, and four patients with scoliosis, aged 12 to 22 years. The latter were studied before, shortly after, and many months after immobilization in plaster casts. On the basis of observed relationships, it appeared that the negative Ca balance observed in the older women was due to the low intensity of the various vectors of Ca metabolism, without clearcut distinction between the subjects with and without osteoporosis. Conversely, in the young patients with scoliosis, the negative balance incident to treatment by immobilization was associated with vectors of relatively high intensity whose relationships were altered temporarily.},
doi = {10.1172/JCI104782},
journal = {Journal of Clinical Investigation},
number = 6,
volume = 42,
place = {Country unknown/Code not available},
year = {Sat Jun 01 00:00:00 EDT 1963},
month = {Sat Jun 01 00:00:00 EDT 1963}
}