Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24

Journal Article · Thu Feb 15 00:00:00 EST 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0088· OSTI ID:466407

Lewis, T B; DuPont, B R; Leach, R ^[1]

---

1. Univ. of Texas Health Science Center, San Antonio, TX (United States); and others

This article reports on the localization of a gene for a glutamate binding subunit of an N-methyl-D-aspartate (NMDA) receptor, called GRINA, to human chromosome 8q24 using fluorescence in situ hybridization and radiation hybridization mapping. This gene mapped outside the critical region for benign familial neonatal convulsions (BFNC), a rare form of epilepsy; however, GRINA could be the causative genetic factor inducing idiopathic generalized epilepsy. Further studies need to be conducted. 15 refs., 2 figs.

• OSTI ID: 466407
• Journal Information: Genomics, Vol. 32, Issue 1; Other Information: PBD: 15 Feb 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
DNA-CLONING
GENETIC MAPPING
DNA SEQUENCING
MUTATION FREQUENCY
GENE MUTATIONS
R CODES
RESOLUTION
HUMAN CHROMOSOME 8
EPILEPSY
PATHOGENESIS
NEONATES
HEREDITARY DISEASES
FLUORESCENCE
DNA HYBRIDIZATION
NUCLEOTIDES
RADIATION INDUCED MUTANTS
TELOMERES
BIOLOGICAL MARKERS
DOMINANT MUTATIONS
PROBES
POLYMERASE CHAIN REACTION