THE BIOSYNTHESIS AND METABOLISM OF OESTROGENS IN THE RAT. 2. THE CONVERSION OF 4-$sup 14$C TESTOSTERONE INTO $sup 14$C OESTRADIOL-17$beta$ BY THE OVARY AFTER WHOLE-BODY IRRADIATION

Journal Article · Mon Jul 01 00:00:00 EDT 1963 · Biochemical Journal (England)

DOI:https://doi.org/10.1042/bj0880076· OSTI ID:4659914

Stitch, S R; Oakey, R E; Eccles, S S

The effect of whole-body irradiation (400 rads) on the ability of the rat ovary to produce estrogen in vitro from (4-C/sup 14/ testosterone at times up to 180 days after irradiation was investigated. After an initial lag, the biosynthesis of estradiol-17 BETA , from 6 days after irradiation onward, appeared to be as high as with tissue from the nonirradiated controls. The biosynthesis of estrogen by ovarian tissue after the destruction of follicular elements by higher doses of irradiation is discussed. (auth)

• Research Organization: Medical Research Council, Radiobiological Research Unit, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-037073
• OSTI ID: 4659914
• Journal Information: Biochemical Journal (England), Vol. Vol: 88; Other Information: Orig. Receipt Date: 31-DEC-63
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BIOCHEMISTRY
BODY
CARBON 14
ESTRADIOL
ESTROGENS
GONADS
HORMONES
IRRADIATION
METABOLISM
OVARIES
RADIATION DOSES
RADIATION EFFECTS
RATS
SEX
STEROIDS
TESTOSTERONE
TRACER TECHNIQUES