POSTIRRADIATION HYPERGLYCEMIA IN THE PRIMATE
Alteration in carbohydrate metabolism resulting from radiation exposure is extensively reported in the literature. Plasma glucose evaluation in rats was found to reach a maximum at 2 to 4 days postirradiation. In other species the level of liver glycogen increased after irradiation. In a study of changes of serum composition following acute radiation in the Macaca mulatta primate, a marked hyperglycemia was observed within 30 min. At 2 hr the glucose level was considerably reduced and was essentially normal at 4 hr post-irradiation. To relate this phenomenon with other species previously reported, rats were irradiated; they did not respond to this immediate glucose burst. Serum response of the rabbit and the dog also failed to demonstrate this very early hyperglycemia. Additional monkeys were then irradiated and in a program utilizing chemical protective compounds it was observed that the preadministration of certain protective materials modified the hyperglycemic response. (auth)
- Research Organization:
- School of Aerospace Medicine, Brooks AFB, Tex.
- NSA Number:
- NSA-17-038885
- OSTI ID:
- 4628907
- Report Number(s):
- SAM-TDR-63-40; CONF-217-1
- Resource Relation:
- Other Information: From Radiation Research Society 11th Annual Meeting, Milwaukee, May 1963. Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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