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Title: Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes

Abstract

Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings. (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates. (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex; another area displays decreased signal intensity upon stimulation. 41 refs., 4 figs.

Authors:
 [1];  [1];  [2]
  1. State Univ. of New York, Stony Brook, NY (United States)
  2. State Univ. of New York, Stony Brook, NY (United States); and others
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
OSTI Identifier:
457016
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 93; Journal Issue: 12; Other Information: PBD: 11 Jun 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; BRAIN; IMAGES; MICE; VISIBLE RADIATION; RESPONSE FUNCTIONS; MAGNETIC RESONANCE; VISION

Citation Formats

Huang, Wei, Brookhaven National Lab., Upton, NY, Laboratory of Neurosciences, Bethesda, MD, Palyka, I, Laboratory of Neurosciences, Bethesda, MD, and Li, HaiFang. Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes. United States: N. p., 1996. Web. doi:10.1073/pnas.93.12.6037.
Huang, Wei, Brookhaven National Lab., Upton, NY, Laboratory of Neurosciences, Bethesda, MD, Palyka, I, Laboratory of Neurosciences, Bethesda, MD, & Li, HaiFang. Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes. United States. https://doi.org/10.1073/pnas.93.12.6037
Huang, Wei, Brookhaven National Lab., Upton, NY, Laboratory of Neurosciences, Bethesda, MD, Palyka, I, Laboratory of Neurosciences, Bethesda, MD, and Li, HaiFang. 1996. "Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes". United States. https://doi.org/10.1073/pnas.93.12.6037.
@article{osti_457016,
title = {Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes},
author = {Huang, Wei and Brookhaven National Lab., Upton, NY and Laboratory of Neurosciences, Bethesda, MD and Palyka, I and Laboratory of Neurosciences, Bethesda, MD and Li, HaiFang},
abstractNote = {Using a 9.4 T MRI instrument, we have obtained images of the mouse brain response to photic stimulation during a period between deep anesthesia and the early stages of arousal. The large image enhancements we observe (often >30%) are consistent with literature results extrapolated to 9.4 T. However, there are also two unusual aspects to our findings. (i) The visual area of the brain responds only to changes in stimulus intensity, suggesting that we directly detect operations of the M visual system pathway. Such a channel has been observed in mice by invasive electrophysiology, and described in detail for primates. (ii) Along with the typical positive response in the area of the occipital portion of the brain containing the visual cortex; another area displays decreased signal intensity upon stimulation. 41 refs., 4 figs.},
doi = {10.1073/pnas.93.12.6037},
url = {https://www.osti.gov/biblio/457016}, journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 12,
volume = 93,
place = {United States},
year = {Tue Jun 11 00:00:00 EDT 1996},
month = {Tue Jun 11 00:00:00 EDT 1996}
}