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Title: Levels of coplanar PCBs in human breast milk at different times of lactation

Abstract

PCBs are a highly lipophilic group of global pollutants, consisting of 209 congeners which exhibit wide differences in their toxic and biological effects. The coplanar PCB (non-, mono- and di-ortho Chlorine substituted) congeners, the most toxic ones, induce similar toxic effects as 2,3,7,8 TCDD. Thus for risk assessment of exposure to PCBs, the analysis of these coplanar congeners is required. The PCB levels in human breast milk are of specific concern because of the potential health damage which may be caused to the nursing baby. The PCB levels in this sample come from previously accumulated quantities in body fat whose principal source is food, and pass directly to the nursing baby who accumulates the PCBs in adipose tissue. The amount of total PCBs and other organochlorine compounds (OCC) in human milk at different time intervals after birth was reported earlier, but data concerning individual and coplanar PCBs are sparse in the literature. The results from some studies showed a gradual decrease of residual levels in milk and milk fat. However, other research has shown differences in this respect. We present our first result concerning the concentration of 14 individual PCBs (13 coplanars) in breast milk from the same mother, duringmore » weeks 8 to 12 of lactation. We related the different concentration variations observed among the individual PCBs to their molecular structure and % fat in human breast milk. 17 refs., 1 fig., 2 tabs.« less

Authors:
; ;  [1]
  1. Institute of Organic Chemistry (CSIC), Madrid (Spain)
Publication Date:
OSTI Identifier:
45295
Resource Type:
Journal Article
Journal Name:
Bulletin of Environmental Contamination and Toxicology
Additional Journal Information:
Journal Volume: 54; Journal Issue: 3; Other Information: PBD: Mar 1995
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; POLYCHLORINATED BIPHENYLS; ECOLOGICAL CONCENTRATION; BIOLOGICAL ACCUMULATION; WOMEN; MAMMARY GLANDS; LACTATION; BIOLOGICAL EFFECTS; MILK

Citation Formats

Gonzalez, M J, Ramos, L, and Hernandez, L M. Levels of coplanar PCBs in human breast milk at different times of lactation. United States: N. p., 1995. Web.
Gonzalez, M J, Ramos, L, & Hernandez, L M. Levels of coplanar PCBs in human breast milk at different times of lactation. United States.
Gonzalez, M J, Ramos, L, and Hernandez, L M. 1995. "Levels of coplanar PCBs in human breast milk at different times of lactation". United States.
@article{osti_45295,
title = {Levels of coplanar PCBs in human breast milk at different times of lactation},
author = {Gonzalez, M J and Ramos, L and Hernandez, L M},
abstractNote = {PCBs are a highly lipophilic group of global pollutants, consisting of 209 congeners which exhibit wide differences in their toxic and biological effects. The coplanar PCB (non-, mono- and di-ortho Chlorine substituted) congeners, the most toxic ones, induce similar toxic effects as 2,3,7,8 TCDD. Thus for risk assessment of exposure to PCBs, the analysis of these coplanar congeners is required. The PCB levels in human breast milk are of specific concern because of the potential health damage which may be caused to the nursing baby. The PCB levels in this sample come from previously accumulated quantities in body fat whose principal source is food, and pass directly to the nursing baby who accumulates the PCBs in adipose tissue. The amount of total PCBs and other organochlorine compounds (OCC) in human milk at different time intervals after birth was reported earlier, but data concerning individual and coplanar PCBs are sparse in the literature. The results from some studies showed a gradual decrease of residual levels in milk and milk fat. However, other research has shown differences in this respect. We present our first result concerning the concentration of 14 individual PCBs (13 coplanars) in breast milk from the same mother, during weeks 8 to 12 of lactation. We related the different concentration variations observed among the individual PCBs to their molecular structure and % fat in human breast milk. 17 refs., 1 fig., 2 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/45295}, journal = {Bulletin of Environmental Contamination and Toxicology},
number = 3,
volume = 54,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 1995},
month = {Wed Mar 01 00:00:00 EST 1995}
}