Genetic linkage study of bipolar disorder and the serotonin transporter
- Univ. of California, San Diego, CA (United States); and others
The serotonin transporter (HTT) is an important candidate gene for the genetic transmission of bipolar disorder. It is the site of action of many antidepressants, and plays a key role in the regulation of serotonin neurotransmission. Many studies of affectively ill patients have found abnormalities in serotonin metabolism, and dysregulation of the transporter itself. The human serotonin transporter has been recently cloned and mapped to chromosome 17. We have identified a PstI RFLP at the HTT locus, and here report our examination of this polymorphism for possible linkage to bipolar disorder. Eighteen families were examined from three populations: the Old Order Amish, Iceland, and the general North American population. In addition to HTT, three other microsatellite markers were examined, which span an interval known to contain HTT. Linkage analyses were conducted under both dominant and recessive models, as well as both narrow (bipolar only) and broad (bipolar + recurrent unipolar) diagnostic models. Linkage could be excluded to HTT under all models examined. Linkage to the interval spanned by the microsatellites was similarly excluded under the dominant models. In two individual families, maximum lod scores of 1.02 and 0.84 were obtained at D17S798 and HTT, respectively. However, these data overall do not support the presence of a susceptibility locus for bipolar disorder near the serotonin transporter. 20 refs., 2 tabs.
- OSTI ID:
- 447664
- Journal Information:
- American Journal of Medical Genetics, Vol. 67, Issue 2; Other Information: PBD: 9 Apr 1996
- Country of Publication:
- United States
- Language:
- English
Similar Records
Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish
Genome scan for linkage to Gilles de la Tourette syndrome
Related Subjects
BASIC STUDIES
GENETICS
STATISTICAL MODELS
NERVOUS SYSTEM DISEASES
PATIENTS
MENTAL DISORDERS
HEREDITARY DISEASES
GENETIC MAPPING
M CODES
HUMAN CHROMOSOME 17
SEROTONIN
DNA-CLONING
GENE MUTATIONS
METABOLISM
RFLPS
BIOLOGICAL MARKERS
DOMINANT MUTATIONS
RECESSIVE MUTATIONS
POLYMERASE CHAIN REACTION