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Title: Chromosomal abnormalities in a psychiatric population

Abstract

Over a 3.5 year period of time, 345 patients hospitalized for psychiatric problems were evaluated cytogenetically. The patient population included 76% males and 94% children with a mean age of 12 years. The criteria for testing was an undiagnosed etiology for mental retardation and/or autism. Cytogenetic studies identified 11, or 3%, with abnormal karyotypes, including 4 fragile X positive individuals (2 males, 2 females), and 8 with chromosomal aneuploidy, rearrangements, or deletions. While individuals with chromosomal abnormalities do not demonstrate specific behavioral, psychiatric, or developmental problems relative to other psychiatric patients, our results demonstrate the need for an increased awareness to order chromosomal analysis and fragile X testing in those individuals who have combinations of behavioral/psychiatric, learning, communication, or cognitive disturbance. 5 refs., 1 fig., 2 tabs.

Authors:
; ; ;  [1]
  1. Univ. of Pittsburgh Medical Center, PA (United States)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
443797
Resource Type:
Journal Article
Resource Relation:
Journal Name: American Journal of Medical Genetics; Journal Volume: 60; Journal Issue: 1; Other Information: PBD: 27 Feb 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOMES; CHROMOSOMAL ABERRATIONS; DETECTION; MENTAL DISORDERS; ETIOLOGY; CHILDREN; KARYOTYPE

Citation Formats

Lewis, K.E., Lubetsky, M.J., Wenger, S.L., and Steele, M.W.. Chromosomal abnormalities in a psychiatric population. United States: N. p., 1995. Web. doi:10.1002/ajmg.1320600110.
Lewis, K.E., Lubetsky, M.J., Wenger, S.L., & Steele, M.W.. Chromosomal abnormalities in a psychiatric population. United States. doi:10.1002/ajmg.1320600110.
Lewis, K.E., Lubetsky, M.J., Wenger, S.L., and Steele, M.W.. Mon . "Chromosomal abnormalities in a psychiatric population". United States. doi:10.1002/ajmg.1320600110.
@article{osti_443797,
title = {Chromosomal abnormalities in a psychiatric population},
author = {Lewis, K.E. and Lubetsky, M.J. and Wenger, S.L. and Steele, M.W.},
abstractNote = {Over a 3.5 year period of time, 345 patients hospitalized for psychiatric problems were evaluated cytogenetically. The patient population included 76% males and 94% children with a mean age of 12 years. The criteria for testing was an undiagnosed etiology for mental retardation and/or autism. Cytogenetic studies identified 11, or 3%, with abnormal karyotypes, including 4 fragile X positive individuals (2 males, 2 females), and 8 with chromosomal aneuploidy, rearrangements, or deletions. While individuals with chromosomal abnormalities do not demonstrate specific behavioral, psychiatric, or developmental problems relative to other psychiatric patients, our results demonstrate the need for an increased awareness to order chromosomal analysis and fragile X testing in those individuals who have combinations of behavioral/psychiatric, learning, communication, or cognitive disturbance. 5 refs., 1 fig., 2 tabs.},
doi = {10.1002/ajmg.1320600110},
journal = {American Journal of Medical Genetics},
number = 1,
volume = 60,
place = {United States},
year = {Mon Feb 27 00:00:00 EST 1995},
month = {Mon Feb 27 00:00:00 EST 1995}
}