Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance

Harris, J W; Bunting, S J

Title: Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance

Full Record
Other Related Research

Authors:: Harris, J W; Bunting, S J

Publication Date:: Tue Oct 31 00:00:00 EST 1950

Research Org.:: Originating Research Org. not identified

OSTI Identifier:: 4421701

Report Number(s):: AECU-885

NSA Number:: NSA-04-005556

Resource Type:: Technical Report

Resource Relation:: Other Information: Orig. Receipt Date: 31-DEC-50

Country of Publication:: Country unknown/Code not available

Language:: English

Subject:: BIOLOGY AND MEDICINE; ANEMIA; ANISOTROPY; BIBLIOGRAPHY; BLOOD; BLOOD VESSELS; COAGULATION; COLLOIDS; CONFIGURATION; DISEASES; DISTILLATION; ERYTHROCYTES; HEMOGLOBIN; HEMOLYSIS; MAN; MOLECULES; REFRACTION; SENSITIVITY; SOLUTIONS; VISCOSITY; WATER

Citation Formats


                    Harris, J W, and Bunting, S J. Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance.  Country unknown/Code not available: N. p., 1950. 
        Web.

Copy to clipboard


                    Harris, J W, & Bunting, S J. Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance.  Country unknown/Code not available.

Copy to clipboard


                    Harris, J W, and Bunting, S J. 1950.  
        "Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance".  Country unknown/Code not available.

Copy to clipboard


                    
@article{osti_4421701,

  title        = {Studies on the Destruction of Red Blood Cells. VIII. Sickle Cell Disease: Molecular Orientation in Solutions of Sickle Cell Hemoglobin and Its Clincial Significance},

  author       = {Harris, J W and Bunting, S J},

  abstractNote = {},

  doi          = {},

  url          = {https://www.osti.gov/biblio/4421701},
  journal      = {},
number       = ,

  volume       = ,

  place        = {Country unknown/Code not available},

  year         = {Tue Oct 31 00:00:00 EST 1950},

  month        = {Tue Oct 31 00:00:00 EST 1950}

}

Copy to clipboard

Technical Report:

Other availability

Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that may hold this item. Keep in mind that many technical reports are not cataloged in WorldCat.

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Examination of adduct formation in vivo in the mouse between benzo(a)pyrene and DNA of skin and hemoglobin of red blood cells

Technical Report Shugart, L; Kao, J

Recent research with HPLC/fluorescence has demonstrated that we can detect, identify, and quantitate the binding of BaP with DNA of mouse skin. The technique not only allows femtomole amounts of BaPDE associated with DNA isolated from a single mouse skin to be detected using conventional instrumenthation, but also establishes the steriochemical origin of the adduct, and has been employed in the investigation reported here to estimate the concomitant binding of BaP to hemoglobin in vivo. The temporal existence of BaPDE/DNA adducts in mouse skin over a 5-week period showed that at 35 days post treatment, approximately 15% of the initialmore »« less
Effects of carbon dioxide and pH variations in vitro on blood respiratory functions, red blood cell volume, transmembrane pH gradients, and sickling in sickle cell anemia

Journal Article Ueda, Y; Bookchin, R - J. Lab. Clin. Med.; (United States)

An examination was made of the O/sub 2/ affinity, Bohr effect, transmembrane pH gradient, mean cell hemoglobin concentration, and red blood cell sickling at half O/sub 2/ saturation in whole sickle cell (SS) and normal (AA) blood during CO/sub 2/ titration and acid-base titration at three Pco/sub 2/ levels, 10, 40, and 80 mm Hg. The CO/sub 2/-induced Bohr effect of SS blood was considerably larger than normal (maximum, 0.91, referred to cell pH) and similar to that found with acid-base titration at Pco/sub 2/ of 40. In contrast to AA blood, SS blood showed an increased O/sub 2/ affinitymore »« less
SURVIVAL OF THE RED BLOOD CELLS OF BLOOD TREATED WITH GENTIAN VIOLET. ITS IMPORTANCE IN THE PROPHYLAXIS OF CHAGAS DISEASE TRANSMITTED DURING TRANSFUSION (in Spanish)

Journal Article Maspes, V; Pieroni, R; Mellone, O - Sangre (Spain)

The utility of adding gentian violet to blood to be transfused for prophylaxis of Chanas disease is discussed. It is quite useful in regions where a high percentage of blood donore are infected, The survivial of the erythrocytes in blood treated with sufficient gentian violet to kill Trypanosoma Cruzi (1: 4,000) is studied. The study was made at 4 deg C with chromium as the labeling substance, Mean cell life values found varied from 66 to 91 days. It was concluded that other properties of erythrcytes are not significantly changed, Therefore, the wide use of gentian violet in the prophylaxismore »« less
Hyperemic peripheral red marrow in a patient with sickle cell anemia demonstrated on Tc-99m labeled red blood cell venography

Journal Article Heiden, R; Locko, R; Stent, T - Clinical Nuclear Medicine; (USA)

A 25-year-old gravid woman, homozygous for sickle cell anemia, with a history of recent deep venous thrombosis, was examined using Tc-99m labeled red blood cell venography for recurrent thrombosis. Although negative for thrombus, the study presented an unusual incidental finding: the patient's peripheral bone marrow was hyperemic in a distribution consistent with peripheral red bone marrow expansion. Such a pattern has not been documented before using this technique. This report supports other literature that has demonstrated hyperemia of peripheral red bone marrow in other hemolytic anemias. This finding may ultimately define an additional role of scintigraphy in assessing the pathophysiologicmore » status of the sickle cell patient.« less
https://doi.org/10.1097/00003072-199103000-00002
A framework of computer vision-enhanced microfluidic approach for automated assessment of the transient sickling kinetics in sickle red blood cells

Journal Article Qiang, Yuhao; Xu, Mengjia; Pochron, Mira; ... - Frontiers in Physics

The occurrence of vaso-occlusive crisis greatly depends on the competition between the sickling delay time and the transit time of individual sickle cells, i.e., red blood cells from sickle cell disease (SCD) patients, while they are traversing the circulatory system. Many drugs for treating SCD work by inhibiting the polymerization of sickle hemoglobin (HbS), effectively delaying the sickling process in sickle cells (SS RBCs). Most previous studies on screening anti-sickling drugs, such as voxelotor, rely on in vitro testing of sickling characteristics, often conducted under prolonged deoxygenation for up to 1 hour. However, since the microcirculation of RBCs typically takes lessmore »« less
https://doi.org/10.3389/fphy.2024.1331047

Similar Records