A convenient synthesis of [C-11]aminocyclo-butanecarboxylic acid [C-11]ACBC
- Univ. of Tennessee Medical Center, Knoxville, TN (United States); and others
[C11]ACBC has been utilized at the University of Tennessee Medical Center for PET oncology studies for almost five years. This radiotracer has demonstrated great utility in identifying malignant tumors. The synthesis of [C-11]ACBC involves a Buecherer-Strecker synthesis carried out at high temperatures and pressures in a high pressure bomb-reactor. The reaction involves condensation of [C-11]cyanide and cylobutanone to form a hydantoin which is then hydrolyzed to the desired amino acid. We wish to report a convenient new procedure which obviates the need for the bomb-reactor. The new method involves the use of a commercially available HPLC injection loop and switching valve. The narrow i.d. stainless steel tubing of the injector loop allows for rapid heating and cooling of the reaction mixtures and easily withstands the high pressures generated during the synthesis. The overall reaction times are less than those required using the bomb-reactor technology which results in an overall increase in radiochemical yield. This improved, rapid procedure can be utilized to radiolabel a variety of natural and unnatural amino acids in the carboxyl position.
- OSTI ID:
- 441621
- Report Number(s):
- CONF-950603-; ISSN 0161-5505; TRN: 96:002093-0046
- Journal Information:
- Journal of Nuclear Medicine, Vol. 36, Issue Suppl.5; Conference: 42. annual meeting of the Society of Nuclear Medicine, Minneapolis, MN (United States), 12-15 Jun 1995; Other Information: PBD: May 1995
- Country of Publication:
- United States
- Language:
- English
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