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Title: Split-brain cats prepared by radiosurgery

Abstract

Cats with their optic chiasma and commissural system disconnected along the mid-sagittal plane are of special value in central nervous system research. The feasibility of producing such split-brain cats with heavy-particle radiation was attempted. Focused, 910-MeV helium ion particles from the Berkeley cyclotron were restricted to a blade-like beam that was oriented to pass between the cerebral hemispheres. Because of their superior non-scattering property, helium particles retained their sharply defined beam even after passage through brain tissue along the cat's longitudinal flssure. The efficiency of helium ions in blocking interhemispheric transfer was tested using electrophysiologic techniques. The corpus callosum was permanently implanted with pairs of wire electrodes in the genu and splenium on either side of the interhemispheric fissure. The time- dose relationship to abolish electrically initiated trans- . callosal action potentials (TCAP) was investigated. The postirradiation interval to inhibit TCAP was an inverse function of the logarithm of the absorbed dose over 10 krads of helium ion radiation. TCAP could be selectively inhibited either in the region of the genu, or the splenium. Transmission of the entire corpus callosum could be blocked by a 2 x 25.4 mm helium ion beam. When the corpus callosurm absorbed less than 10more » krads of helium ions TCAP were not abolished. A very fine helium ion beam, 0.5 x 25.4 mm, was not successful in halting TCAP, even though the corpus callosum absorbed 50 krads of radiation. The radiovulnerability of the small-calibre nerve fibres (1 mu and less) that constitute the corpus callosum is discussed. (auth)« less

Authors:
;
Publication Date:
Research Org.:
Univ. of California, Berkeley
OSTI Identifier:
4405216
NSA Number:
NSA-29-002933
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Biol., v. 24, no. 3, pp. 229-242
Additional Journal Information:
Other Information: Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: UK (United Kingdom (sent to DOE from))
Country of Publication:
United Kingdom
Language:
English
Subject:
N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates; *BRAIN- BIOLOGICAL RADIATION EFFECTS; *HELIUM IONS- BIOLOGICAL RADIATION EFFECTS; *SURGERY- HELIUM IONS; CATS; DOSE-RESPONSE RELATIONSHIPS; ION BEAMS; MEV RANGE 100-1000; RADIOTHERAPY; RESPONSE MODIFYING FACTORS; TIME DEPENDENCE

Citation Formats

Gaffey, C T, and Montoya, V J. Split-brain cats prepared by radiosurgery. United Kingdom: N. p., 1973. Web. doi:10.1080/09553007314551081.
Gaffey, C T, & Montoya, V J. Split-brain cats prepared by radiosurgery. United Kingdom. https://doi.org/10.1080/09553007314551081
Gaffey, C T, and Montoya, V J. 1973. "Split-brain cats prepared by radiosurgery". United Kingdom. https://doi.org/10.1080/09553007314551081.
@article{osti_4405216,
title = {Split-brain cats prepared by radiosurgery},
author = {Gaffey, C T and Montoya, V J},
abstractNote = {Cats with their optic chiasma and commissural system disconnected along the mid-sagittal plane are of special value in central nervous system research. The feasibility of producing such split-brain cats with heavy-particle radiation was attempted. Focused, 910-MeV helium ion particles from the Berkeley cyclotron were restricted to a blade-like beam that was oriented to pass between the cerebral hemispheres. Because of their superior non-scattering property, helium particles retained their sharply defined beam even after passage through brain tissue along the cat's longitudinal flssure. The efficiency of helium ions in blocking interhemispheric transfer was tested using electrophysiologic techniques. The corpus callosum was permanently implanted with pairs of wire electrodes in the genu and splenium on either side of the interhemispheric fissure. The time- dose relationship to abolish electrically initiated trans- . callosal action potentials (TCAP) was investigated. The postirradiation interval to inhibit TCAP was an inverse function of the logarithm of the absorbed dose over 10 krads of helium ion radiation. TCAP could be selectively inhibited either in the region of the genu, or the splenium. Transmission of the entire corpus callosum could be blocked by a 2 x 25.4 mm helium ion beam. When the corpus callosurm absorbed less than 10 krads of helium ions TCAP were not abolished. A very fine helium ion beam, 0.5 x 25.4 mm, was not successful in halting TCAP, even though the corpus callosum absorbed 50 krads of radiation. The radiovulnerability of the small-calibre nerve fibres (1 mu and less) that constitute the corpus callosum is discussed. (auth)},
doi = {10.1080/09553007314551081},
url = {https://www.osti.gov/biblio/4405216}, journal = {Int. J. Radiat. Biol., v. 24, no. 3, pp. 229-242},
number = ,
volume = ,
place = {United Kingdom},
year = {Sat Sep 01 00:00:00 EDT 1973},
month = {Sat Sep 01 00:00:00 EDT 1973}
}