Viruses in osteosarcomas induced by $sup 226$Ra. A study of the induction of bone tumors in mice

Technical Report · Mon Jan 01 00:00:00 EST 1973

OSTI ID:4371261

Lloyd, E L; Loutit, J F; Mackevicius, F

ABS>Radiological and Environmental Research Division annual report, July 1972-June 1973. Three groups (15 in each group) of 3-month-old mice were injected i.p. with 1/2 mu Ci /sup 226/Ra. These groups were matched by similar control animals, which were not injected. Osteosarcomas were found in 40% of the male C3H/H mice and 80% of the female C3H/H mice, animals known to carry mammary viruses. No osteosarcomas were found in the female CBA/H mice, which have a very low incidence of both mammary tumors and leukemias. Viruses were observed in both mammary tumors and in osteosarcomas, which developed in the same animals. The possible association of virus in both types of tumors is discussed. (auth)

• Research Organization: Argonne National Lab., Ill. (USA)
• NSA Number: NSA-29-013041
• OSTI ID: 4371261
• Report Number(s): ANL-8060(Pt.2)
• Resource Relation: Other Information: Orig. Receipt Date: 30-JUN-74; Related Information: Radiological and Environmental Research Division annual report, July 1972-- June 1973
• Country of Publication: United States
• Language: English

Related Subjects

N48620* -Life Sciences-Radionuclide Effects (Internal Source)-Animals
*NEOPLASMS- VIRUSES
*OSTEOSARCOMAS- RADIOINDUCTION
*RADIUM 226- BIOLOGICAL RADIATION EFFECTS
CARCINOGENS
CHRONIC IRRADIATION
ETIOLOGY
INTERNAL IRRADIATION
INTRAPERITONEAL INJECTION
LOW DOSE IRRADIATION
MAMMARY GLANDS
MICE
RADIATION DOSES
TOXICITY RADIOINDUCTION