The Susceptibility of the Hypothalamic-Pituitary-Adrenocortical Axis to Histamine after Head X-Irradiation
Under pentobarbital anesthesia, adult male dogs were irradiated with 1,000 R of x rays to their heads, and the adrenocortical response to histamine was investigated. The secretory activity was OHCS from the adrenal, but the response was significantly less than that in non-irradiated animals. Thirty days after exposure, irradiated animals responded to the injection of histannine and secreted an appreciably large amounnt of 17- OHCS. However, the responsiveness was still lower than normal. At appears from these results that the corticotrophic effect of 0.5 mg histamine/kg can be diminished considerably by pretreatment with head x irradiation of 1,000 R, possibly due to a disturbed activity of the hypothalamicpituitary axis. (auth)
- Research Organization:
- Nagasaki Univ.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-021208
- OSTI ID:
- 4351478
- Journal Information:
- Tohoku Journal of Experimental Medicine, Vol. 110, Issue 2; Other Information: Orig. Receipt Date: 30-JUN-74; ISSN 0040-8727
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
RADIATION OF PARIETAL CELLS WITH AND WITHOUT HISTAMINE STIMULATION
ADRENOCORTICAL RESERVE IN PATIENTS WITH GENITAL CARCINOMA