Progress in designing small inhibitors which discriminate among trypsin- like enzymes
Technical Report
·
OSTI ID:4347864
Earligr work on the affinity labeling of trypsin was extended in the direction of obtaining more selective agents. The choice of trypsin-like target enzymes was somewhat arbitrarily made, but a number of reagents were devised that can discriminate between individuals of a pair of trypsin-like enzymes. In one case, nitrophenyl p-amidinophenylmethanesulfonate, even more remarkable selectivity was obtained. It is concluded that, although trypsin-like enzymes may all be homologous and therefore possess very similar active centers, apparently reactivity differences exist that offer a basis for selective inactivation by small molecule inhibitors. (8 figures, 23 references) (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y. (USA)
- NSA Number:
- NSA-29-017978
- OSTI ID:
- 4347864
- Report Number(s):
- BNL-18364; CONF-731055-1
- Resource Relation:
- Conference: 5. international symposium on proteinase inhibitors, Grosse Ledder, F.R. Germany, 17 Oct 1973; Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- United States
- Language:
- English
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