METABOLISM OF ESSENTIAL FATTY ACIDS. VII. CONVERSION OF $gamma$-LINOLENIC ACID TO ARACHIDONIC ACID

Journal Article · Sun Dec 01 00:00:00 EST 1957 · Journal of Biological Chemistry (U.S.)

OSTI ID:4339471

Mead, J F; Howton, D R

Methyl gamma -linolenate-1-C/sup 14/ was fed to rats, and the fatty acids of depot and organ lipides of the rats were separated chromatographically and counted. The sole highly active fatty acid was arachidonic, which, after hydrogenation and degradation in three steps, was found to have 97% of the activity in carbon atom 3. These results support the hypothesis that gamma - linolenic acid is an intermediate in the conversion of linoleic acid to arachidonic acid. (auth)

• Research Organization: Univ. of California, Los Angeles
• NSA Number: NSA-12-004131
• OSTI ID: 4339471
• Journal Information: Journal of Biological Chemistry (U.S.), Vol. Vol: 229; Other Information: Orig. Receipt Date: 31-DEC-58
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

CHEMISTRY
ARACHIDONIC ACID
BIOCHEMISTRY
CARBON 14
CHEMICAL REACTIONS
CHROMATOGRAPHY
COUNTERS
DECOMPOSITION
FOOD
HYDROGENATION
LABELLED COMPOUNDS
LINOLENIC ACID
LIPIDS
METABOLISM
ORGANIC ACIDS
RATS
REACTION KINETICS
SEPARATION PROCESSES