Mapping of the mouse macrophage inflammatory protein-1{alpha} receptor gene Scya3r and two related mouse {beta} chemokine receptor-like genes to chromosome 9
- National Institutes of Health, Bethesda, MD (United States)
Macrophage inflammatory protein-1{alpha} (MIP-1{alpha}) and RANTES are members of the {beta} chemokine family of leukocyte chemoattractants. We have previously cloned three mouse genes by cross-hybridization with the human MIP-1{alpha}/RANTES receptor gene CMKBR1. One of the mouse genes, Scya3r, encodes a functional MIP-1{alpha} receptor. The functions of the other two, Scya3r-rs1 and Scya3r-rs2, are not known. We have now mapped Scya3r, Scya3r-rs1, and Scya3r-rs2 to chromosome 9, in a region of conserved synteny with the location of CMKBR1. Thus, like chemokine genes and {alpha} chemokine receptor genes, this group of {Beta} chemokine receptor genes arose by tandem duplication. 17 refs., 2 figs.
- OSTI ID:
- 433320
- Journal Information:
- Genomics, Vol. 29, Issue 1; Other Information: PBD: 1 Sep 1995
- Country of Publication:
- United States
- Language:
- English
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