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Title: RADIATION INDUCED AGING IN MICE

Abstract

. Experiments were undertaken in an effort to determine the degree of similarity between natural and radiation induced aging, and to determine the causes for the latter. Several severe non-specific stresses were applied to mice either as single massive doses or as smaller doses administered over a large fraction of the life span of the animals. Stresses used included typhoid vaccine, tetanus toxin and tetanus toxoid and turpentine. None of these produced any premature aging comparable to that produced by radiation. The somatic mutation theory of aging and expecially radiationinduced aging has been tested by applying the chemical mutatgen, nitrogen mustard, either as a massive single dose or as smaller single doses repeated over long periods of time. No shortening of the life span has been observed and it is concluded that the somatic mutation theory is untenable. Experiments designed to determine the organ system responsible for radiation induced aging have demonstrated that the hematopoietic system is not primarily involved in this phenomenon. (auth)

Authors:
;
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, N.Y.
OSTI Identifier:
4323832
Report Number(s):
A/CONF.15/P/912
NSA Number:
NSA-12-014506
Resource Type:
Technical Report
Resource Relation:
Other Information: Prepared for the Second U.N. International Conference on the Peaceful Uses of Atomic Energy, 1958. Orig. Receipt Date: 31-DEC-58
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; AGE; BLOOD FORMATION; CHEMICALS; CONFERENCE; DRUGS; HYDROCARBONS; INFECTIONS; MICE; MICROORGANISMS; MUTATIONS; NITROGEN MUSTARD; ORGANIC NITROGEN COMPOUNDS; PROTEINS; QUANTITY RATIO; RADIATION EFFECTS; SENSITIVITY; TERPENTINE; TETANUS; TISSUES; TOXICITY; VACCINES; VARIATIONS

Citation Formats

Curtis, H.J., and Gebhard, K.L. RADIATION INDUCED AGING IN MICE. Country unknown/Code not available: N. p., 1958. Web.
Curtis, H.J., & Gebhard, K.L. RADIATION INDUCED AGING IN MICE. Country unknown/Code not available.
Curtis, H.J., and Gebhard, K.L. Fri . "RADIATION INDUCED AGING IN MICE". Country unknown/Code not available.
@article{osti_4323832,
title = {RADIATION INDUCED AGING IN MICE},
author = {Curtis, H.J. and Gebhard, K.L.},
abstractNote = {. Experiments were undertaken in an effort to determine the degree of similarity between natural and radiation induced aging, and to determine the causes for the latter. Several severe non-specific stresses were applied to mice either as single massive doses or as smaller doses administered over a large fraction of the life span of the animals. Stresses used included typhoid vaccine, tetanus toxin and tetanus toxoid and turpentine. None of these produced any premature aging comparable to that produced by radiation. The somatic mutation theory of aging and expecially radiationinduced aging has been tested by applying the chemical mutatgen, nitrogen mustard, either as a massive single dose or as smaller single doses repeated over long periods of time. No shortening of the life span has been observed and it is concluded that the somatic mutation theory is untenable. Experiments designed to determine the organ system responsible for radiation induced aging have demonstrated that the hematopoietic system is not primarily involved in this phenomenon. (auth)},
doi = {},
journal = {},
number = ,
volume = ,
place = {Country unknown/Code not available},
year = {Fri Oct 31 00:00:00 EST 1958},
month = {Fri Oct 31 00:00:00 EST 1958}
}

Technical Report:
Other availability
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