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Title: Experimental investigation of filtered epithermal photoneutron beams for BNCT

Abstract

Epithermal neutron beams having sufficient intensities for the clinical application of boron neutron capture therapy (BNCT) for cancer are currently produced using small nuclear reactors. A practical accelerator neutron source for BNCT would offer some advantages over the reactor-based approach, and a few low-intensity prototypes of such sources, generally featuring the use of deuteron or proton beams and beryllium or lithium targets, have been constructed and tested. Scaling of these devices to output levels suitable for clinical application will in many cases require additional developments in the relevant accelerator technology, as well as the resolution of some rather difficult issues associated with target cooling. This paper provides new experimental performance data for an alternate concept for the realization of a clinically useful accelerator-based source of epithermal neutrons for BNCT that is based on the use of a two-stage photoneutron production process driven by an electron accelerator. Computational design data as well as benchtopscale experimental results obtained to date show that reconciliation of the conflicting objectives of target cooling, neutron beam intensity, and neutron beam spectral purity that are inherent in the design of essentially all proposed accelerator neutron sources for BNCT may very well be achievable in a practical clinicalmore » device based on the photoneutron concept.« less

Authors:
; ; ;  [1]
  1. Idaho State Univ., Pocatello, ID (United States)
Publication Date:
OSTI Identifier:
426301
Report Number(s):
CONF-961103-
Journal ID: TANSAO; ISSN 0003-018X; TRN: 96:006307-0021
Resource Type:
Journal Article
Journal Name:
Transactions of the American Nuclear Society
Additional Journal Information:
Journal Volume: 75; Conference: Winter meeting of the American Nuclear Society (ANS) and the European Nuclear Society (ENS), Washington, DC (United States), 10-14 Nov 1996; Other Information: PBD: 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 43 PARTICLE ACCELERATORS; EPITHERMAL NEUTRONS; NEUTRON CAPTURE THERAPY; PHOTONEUTRONS; BEAM PRODUCTION; BORON; ELECTRON BEAMS; ACCELERATORS

Citation Formats

Nigg, D W, Mitchell, H E, Harker, Y D, and Harmon, J F. Experimental investigation of filtered epithermal photoneutron beams for BNCT. United States: N. p., 1996. Web.
Nigg, D W, Mitchell, H E, Harker, Y D, & Harmon, J F. Experimental investigation of filtered epithermal photoneutron beams for BNCT. United States.
Nigg, D W, Mitchell, H E, Harker, Y D, and Harmon, J F. Tue . "Experimental investigation of filtered epithermal photoneutron beams for BNCT". United States.
@article{osti_426301,
title = {Experimental investigation of filtered epithermal photoneutron beams for BNCT},
author = {Nigg, D W and Mitchell, H E and Harker, Y D and Harmon, J F},
abstractNote = {Epithermal neutron beams having sufficient intensities for the clinical application of boron neutron capture therapy (BNCT) for cancer are currently produced using small nuclear reactors. A practical accelerator neutron source for BNCT would offer some advantages over the reactor-based approach, and a few low-intensity prototypes of such sources, generally featuring the use of deuteron or proton beams and beryllium or lithium targets, have been constructed and tested. Scaling of these devices to output levels suitable for clinical application will in many cases require additional developments in the relevant accelerator technology, as well as the resolution of some rather difficult issues associated with target cooling. This paper provides new experimental performance data for an alternate concept for the realization of a clinically useful accelerator-based source of epithermal neutrons for BNCT that is based on the use of a two-stage photoneutron production process driven by an electron accelerator. Computational design data as well as benchtopscale experimental results obtained to date show that reconciliation of the conflicting objectives of target cooling, neutron beam intensity, and neutron beam spectral purity that are inherent in the design of essentially all proposed accelerator neutron sources for BNCT may very well be achievable in a practical clinical device based on the photoneutron concept.},
doi = {},
journal = {Transactions of the American Nuclear Society},
number = ,
volume = 75,
place = {United States},
year = {1996},
month = {12}
}