Autism and genetics: Clinical approach and association study with two markers of HRAS gene

Journal Article · Mon Aug 14 00:00:00 EDT 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600404· OSTI ID:426172

Herault, J; Petit, E; Cherpi, C ^[1]

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1. Laboratoire de Biochimie Medicale, Tours (France); and others

Twin studies and familial aggregation studies indicate that genetic factors could play a role in infantile autism. In an earlier study, we identified a possible positive association between autism and a c-Harvey-ras (HRAS) oncogene marker at the 3{prime} end of the coding region. In an attempt to confirm this finding, we studied a larger population, well-characterized clinically and genetically. We report a positive association between autism and two HRAS markers, the 3{prime} marker used in the initial study and an additional marker in exon 1. 46 refs., 1 fig., 2 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 426172
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 4; Other Information: PBD: 14 Aug 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MENTAL DISORDERS
GENETICS
ONCOGENES
GENE MUTATIONS
INFANTS
BEHAVIOR
HEREDITARY DISEASES
BIOLOGICAL MARKERS
EXONS
RFLPS
POLYMERASE CHAIN REACTION
STATISTICS