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Title: BIOLOGICAL AND MEDICAL RESEARCH DIVISION SEMIANNUAL REPORT FOR JANUARY THROUGH JUNE 1958

Abstract

The hemolysin system in gamma-irradiated rabbits was used in a study of the qualitative as well as the quantitative characteristics of the radiosensitivity of antibody production. Applications of IBM equipment in the analysis of biological data are discussed. Cytological features are described which were obscrved in buckwheat grown in carton dioxide containing carbon14. Electron microscopic observations are described which were made on the ovotestis of a pulmonate snail and on ciliate nuclear phenomena in Tetrahymena. Results are reported from a study of the comparative carcinogenicity of radium-226, strontium-90, and calcium-45 in mice. Results of tracer studies on metabolism in cultures of Escherichia coli indicate that in growing cultures of bacterias intracellular protein degradation and nucleic acid degradation do not occur and that under normal conditions cell death rarely occurs. Data on the heterologous growth of mouse ascites tumor in the rat are summarized. Observations on radiation injuries in chick embryos following exposure to cobalt-60 gamma radiation suggest two distinct modes of radiation injury. Findings are discussed. Progress is reported in the following studies: investigations of the heat-stable factor necessary for inhibition of catalase; the enzymatic decomposition of S- adenosylmethionine and methylthioadenosine; protein synthesis in the pancreas; the response of variousmore » mouse strains and hybrids to daily dosages of cobalt-60 gamma radiation; the effects of heavy water on kidneys and liver of rats; the effect of x radiation on the intracellular distribution of cytochrome oxidase in the rat thymus; the dependence of acute and subacute radiosensitivity on age in mice; the rate of recovery from radiation injury~; the effect of fractionation of dose on biological effects of fission neutrons; the relative biological cffectiveness of fission neutrons and cobalt-60 gamma radiation evaluated by 15 different biological tests on a widely varying group of plants and animals; the life-shortening effect of whole-body exposure to ionizing radiation in mice; the effectiveness of new chelating agents in the treatment of plutonium poisoning; the effects of radiotoxic levels of gamma-emitting isotopes on distribution and retention patterns established by tracer methods; the effects of ultraviolet radiation on amoebae; tracer studies on the life cycle of leukocytes; the dynamics of the release of histamine from tissue mast cells; the effect of repeated paracentesis on the growth of Ehrlich ascites tumor cells in mice; the effects of deuterium oxicie in drinking water on pregnancy and on viability of newbom mice; the radioactivity of grass grown on thorium-bearing sand; and tracer studies on the metabolism of proteins, fatty acidss and cholesterol. (For preceding period see ANL-5841.) (C.H.)« less

Publication Date:
Research Org.:
Argonne National Lab., Lemont, Ill.
OSTI Identifier:
4249363
Report Number(s):
ANL-5916
NSA Number:
NSA-13-014143
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Technical Report
Resource Relation:
Other Information: Orig. Receipt Date: 31-DEC-59
Country of Publication:
United States
Language:
English
Subject:
BIOLOGY AND MEDICINE; ADENOSINE- AMINO ACIDS- CHEMICAL REACTIONS- DECOMPOSITION- ENZYMES- METHIONINE- ORGANIC SULFUR COMPOUNDS- RIBONUCLEIC ACID; AGE- BODY- GAMMA RADIATION- MICE- RADIATION DOSES- RADIATION EFFECTS- SURVIVAL TIME- X RADIATION; AGE- DEUTERIUM- FETUSES- FREQUENCY- HEAVY WATER- MICE- SENSITIVITY- WATER; AGE- MICE- RADIOSENSITIVITY- VARIATIONS; AMINES- CYTOLOGY- HISTAMINE- MAST CELLS- PHYSIOLOGY- PRODUCTION- TISSUES; AMOEBA- MICROORGANISMS- RADIATION EFFECTS- ULTRAVIOLET RADIATION; ANIMAL CELLS- ASCITES TUMOR- CANCER- MICE- RATS- TRANSPLANTS- TUMORS; ANIMAL CELLS- CYTOCHROME OXIDASE- DISTRIBUTION- ENZYMES- RA

Citation Formats

None. BIOLOGICAL AND MEDICAL RESEARCH DIVISION SEMIANNUAL REPORT FOR JANUARY THROUGH JUNE 1958. United States: N. p., 1958. Web. doi:10.2172/4249363.
None. BIOLOGICAL AND MEDICAL RESEARCH DIVISION SEMIANNUAL REPORT FOR JANUARY THROUGH JUNE 1958. United States. doi:10.2172/4249363.
None. Mon . "BIOLOGICAL AND MEDICAL RESEARCH DIVISION SEMIANNUAL REPORT FOR JANUARY THROUGH JUNE 1958". United States. doi:10.2172/4249363. https://www.osti.gov/servlets/purl/4249363.
@article{osti_4249363,
title = {BIOLOGICAL AND MEDICAL RESEARCH DIVISION SEMIANNUAL REPORT FOR JANUARY THROUGH JUNE 1958},
author = {None},
abstractNote = {The hemolysin system in gamma-irradiated rabbits was used in a study of the qualitative as well as the quantitative characteristics of the radiosensitivity of antibody production. Applications of IBM equipment in the analysis of biological data are discussed. Cytological features are described which were obscrved in buckwheat grown in carton dioxide containing carbon14. Electron microscopic observations are described which were made on the ovotestis of a pulmonate snail and on ciliate nuclear phenomena in Tetrahymena. Results are reported from a study of the comparative carcinogenicity of radium-226, strontium-90, and calcium-45 in mice. Results of tracer studies on metabolism in cultures of Escherichia coli indicate that in growing cultures of bacterias intracellular protein degradation and nucleic acid degradation do not occur and that under normal conditions cell death rarely occurs. Data on the heterologous growth of mouse ascites tumor in the rat are summarized. Observations on radiation injuries in chick embryos following exposure to cobalt-60 gamma radiation suggest two distinct modes of radiation injury. Findings are discussed. Progress is reported in the following studies: investigations of the heat-stable factor necessary for inhibition of catalase; the enzymatic decomposition of S- adenosylmethionine and methylthioadenosine; protein synthesis in the pancreas; the response of various mouse strains and hybrids to daily dosages of cobalt-60 gamma radiation; the effects of heavy water on kidneys and liver of rats; the effect of x radiation on the intracellular distribution of cytochrome oxidase in the rat thymus; the dependence of acute and subacute radiosensitivity on age in mice; the rate of recovery from radiation injury~; the effect of fractionation of dose on biological effects of fission neutrons; the relative biological cffectiveness of fission neutrons and cobalt-60 gamma radiation evaluated by 15 different biological tests on a widely varying group of plants and animals; the life-shortening effect of whole-body exposure to ionizing radiation in mice; the effectiveness of new chelating agents in the treatment of plutonium poisoning; the effects of radiotoxic levels of gamma-emitting isotopes on distribution and retention patterns established by tracer methods; the effects of ultraviolet radiation on amoebae; tracer studies on the life cycle of leukocytes; the dynamics of the release of histamine from tissue mast cells; the effect of repeated paracentesis on the growth of Ehrlich ascites tumor cells in mice; the effects of deuterium oxicie in drinking water on pregnancy and on viability of newbom mice; the radioactivity of grass grown on thorium-bearing sand; and tracer studies on the metabolism of proteins, fatty acidss and cholesterol. (For preceding period see ANL-5841.) (C.H.)},
doi = {10.2172/4249363},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1958},
month = {9}
}