LATE EFFECTS OF TOTAL-BODY ROENTGEN IRRADIATION. V. LONGEVITY AND INCIDENCE OF NEPHROSCLEROSIS AS INFLUENCED BY PARTIAL-BODY SHIELDING
After receiving 1000 r, hypoxic, total- or partialbody irradiation, 242 female Wistar rats were observed throughout their life span. Hypoxic irradiation with superimposed anesthesia resulted in 67 percent, 30day mortality. Selection of the colony by acute postirradiation deaths did not influence the magnitude of late radiation sequelae as measured by life-shortening. Growth retardation during the 2d post-irradiation year was well correlated with life-shortening. Life-shortening was observed after partial-body irradiation, to an extent approximately proportional to the weight of irradiated tissue. Nephrosclerosis was not observed unless the upper abdomen was included within the radiation field. Other than nephrosclerosis, a similar incidence of disease was observed, at deaths in control and partial- or total-body irradiated rats. (auth)
- Research Organization:
- Univ. of California, Los Angeles
- NSA Number:
- NSA-13-014178
- OSTI ID:
- 4247373
- Journal Information:
- Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Vol. Vol: 22; Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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