Electron microscopic study of spontaneous and experimentally induced leukemia in IRC mice

Journal Article · Fri Mar 01 00:00:00 EDT 1974 · Cancer Res., v. 34, pp. 474-483

OSTI ID:4182393

Hiraki, S; Ranadive, K J; Dmochowski, L

Spontaneous, serially transplanted, and experimentally induced leukemias of ICRC mice were studied by electron microscopy in an attempt to detect the presence of virus particles, if any, and to observe the influence of chemical and hormonal treatment on the presence of these virus particles. The first series of experiments included spontaneous, serially transplanted, and radiation-induced leukemia. The paucity of type C virus particles was quite conspicuous in spontaneous leukemia. Serially transplanted and radiation-accelerated leukemic lesions showed the presence of some type C and intracisternal type A particles. Found in two of these leukemic lesions (thymus and lymphosarcoma), in addition to type C virus particles, were budding and some mature type B virus particles, and numerous intracytoplasmic type A particles. ''Viropexis'' of type B virus particles has been observed in the lymphosarcoma and in a leukemic thymus gland. The second series of experiments included leukemia induced in ovariectomized ICRC mice with 20-methylcholanthrene (MCA), pituitary transplants, and ovarian hormones (estradiol and estradiol-progesterone). In ovariectomized ICRC mice, leukemic lesions induced by MCA or pituitary transplants, or by MCA and pituitary transplants, showed type C virus particles and, in most cases, intracisternal type A particles. In leukemia induced in ovariectomized ICRC mice by MCA and estradiol, numerous intracytoplasmic type A particles were observed but no type C virus particles. (auth)

• Research Organization: Univ. of Texas System Cancer Center, Houston
• NSA Number: NSA-33-005784
• OSTI ID: 4182393
• Journal Information: Cancer Res., v. 34, pp. 474-483, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates
560152* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Vertebrates
*CHOLANTHRENE- BIOLOGICAL EFFECTS
*ESTRADIOL- BIOLOGICAL EFFECTS
*HORMONES- BIOLOGICAL EFFECTS
*LEUKEMIA- RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
MICE
OVARIES
PARTICLES
PITUITARY GLAND
RADIATIONS
TRANSPLANTS
VIRUSES