The development of the mammalian nervous system I. Malformations of the brain, especially the cerebral cortex, induced in rats by radiation II. Some mechanisms of the malformations of the cortex

Journal Article · Tue Dec 01 00:00:00 EST 1959 · Journal of Comparative Neurology

DOI:https://doi.org/10.1002/cne.901130306· OSTI ID:4180022

Hicks, Samuel P.; D'Amato, Constance J.; Lowe, Mary Jane

Radiation can be used to induced series of developmentall malformations in the brains of rats The degree of reproducibility of the patterns has suggested their use in studies relating certain attributes of behavior with cerebral cortical structure. The patterns of brain malformiation induced by giving 150 to 200 r on each of the days of gestation. 12 to 20. are described and illustrated. Some of the histogenetic mechanisms that lead up to the cortical malformations are described. based on a study of different members of the same abnormal litter taken at successive stages of development.

• Research Organization: New England Deaconess Hospital, Boston; Harvard Medical School, Boston
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-021320
• OSTI ID: 4180022
• Journal Information: Journal of Comparative Neurology, Vol. 113, Issue 3; Other Information: Orig. Receipt Date: 31-DEC-60; ISSN 0021-9967
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
GENETICS
MALFORMATIONS
PREGNANCY
RADIATION DOSES
RADIATION EFFECTS
RATS