GAMMA RADIATION OF EYE MEDICAMENTS
The use of x rays to sterilize ophthalmological pharmaceutical preparations is described, particularly penicillin and fluorescein drops. The method used with penicillin is to place a tablet (1500 units) in a small vial which is closed with a cork and attached with Sellotape to a 5-ml eye-drop bottle containing 3 ml of normal saline. The bottles were sealed in two polythene envelopes and irradiated at the Wantage Research Lab (AERE) at a dose of 2.5 Mrad. The bags are then stored in a refrigerator at 4 deg C. When required for operation, the outer bag is opened with sterile scissors, and the contents tipped onto the surface of the sterile instrument tray. The dropper bulb is filled with saline and introduced into the vial, thereby dissolving the tablet of penicillin. All irradiated preparations were found to be absolutely sterile and fully potent. In the case of fluorescein, 1-in. lengths of gauge 2-intraarterial polythene tubes are filled with the dye from a syringe, and the ends of the tube sealed in a flame. Several hundreds of tubes are irradiated in a single container, and when required, one end of the tube is cut off and a drop squeezed out into the conjunctival sac. (BBB)
- Research Organization:
- Salisbury General Hospital, Eng.
- NSA Number:
- NSA-18-000525
- OSTI ID:
- 4167082
- Journal Information:
- Lancet (England), Vol. Vol: 2; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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