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Title: STUDIES ON RADIATION-INDUCED TANNING OF SKIN

Abstract

After repeated exposure to uv, hyperpigmentation developed in the general body skin of hairless mice and in the plantar skin of mice of a number of strains selected on the basis of characteristic differences in coat coloration. The hyperpigmentation was due largely to an increase in melanin synthesis by epidermal melanocytes. The major coat color genes had a profound effect on this process by having an influence on melanocyte distribution and, possibly, proliferation; the numbers of melanocytes activated by uv radiation; the amount of pigment synthesized by melanocytes, either retained by them or transferred to epidermal cells; the color and size of pigment granules elaborated by melandocytes; and the shape of the melanocytes. Possible mechanisms involved in the response of epidermal melanocytes to radiations are discussed. (auth)

Authors:
;
Publication Date:
Research Org.:
Brown Univ., Providence and Roswell Park Memorial Inst., Springville, N.Y.
OSTI Identifier:
4163173
NSA Number:
NSA-18-005017
Resource Type:
Journal Article
Resource Relation:
Journal Name: Annals of the New York Academy of Sciences (U.S.); Journal Volume: Vol: 100; Other Information: Orig. Receipt Date: 31-DEC-64
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; BIOCHEMISTRY; BODY; CYTOLOGY; DISTRIBUTION; GENETICS; MELANIN; MELANOCYTES; MICE; MITOSIS; PIGMENTS; QUANTITY RATIO; RADIATION EFFECTS; SKIN; ULTRAVIOLET RADIATION; VARIATIONS

Citation Formats

Quevedo, W.C. Jr., and Smith, J.A.. STUDIES ON RADIATION-INDUCED TANNING OF SKIN. Country unknown/Code not available: N. p., 1963. Web.
Quevedo, W.C. Jr., & Smith, J.A.. STUDIES ON RADIATION-INDUCED TANNING OF SKIN. Country unknown/Code not available.
Quevedo, W.C. Jr., and Smith, J.A.. Fri . "STUDIES ON RADIATION-INDUCED TANNING OF SKIN". Country unknown/Code not available.
@article{osti_4163173,
title = {STUDIES ON RADIATION-INDUCED TANNING OF SKIN},
author = {Quevedo, W.C. Jr. and Smith, J.A.},
abstractNote = {After repeated exposure to uv, hyperpigmentation developed in the general body skin of hairless mice and in the plantar skin of mice of a number of strains selected on the basis of characteristic differences in coat coloration. The hyperpigmentation was due largely to an increase in melanin synthesis by epidermal melanocytes. The major coat color genes had a profound effect on this process by having an influence on melanocyte distribution and, possibly, proliferation; the numbers of melanocytes activated by uv radiation; the amount of pigment synthesized by melanocytes, either retained by them or transferred to epidermal cells; the color and size of pigment granules elaborated by melandocytes; and the shape of the melanocytes. Possible mechanisms involved in the response of epidermal melanocytes to radiations are discussed. (auth)},
doi = {},
journal = {Annals of the New York Academy of Sciences (U.S.)},
number = ,
volume = Vol: 100,
place = {Country unknown/Code not available},
year = {Fri Feb 15 00:00:00 EST 1963},
month = {Fri Feb 15 00:00:00 EST 1963}
}