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Title: Effects of stable iodide blocking of exposure to radioiodine. Progress report, November 1, 1974--October 31, 1975

Abstract

Results are reported from studies on the influence of dietary iodine intake on the uptake of $sup 131$I by the thyroid gland of beagles. A model of iodine kinetics in normal dogs was developed that consists of separate subsystems for iodine, thyroxine, triiodothyronine, and the thyroid gland. The model demonstrates important differences in iodine metabolism and thyroid function between the dog and man. (CH)

Authors:
;
Publication Date:
Research Org.:
Duke Univ., Durham, N.C. (USA). Dept. of Zoology
OSTI Identifier:
4153145
Report Number(s):
COO-3173-14
NSA Number:
NSA-33-003289
DOE Contract Number:
E(11-1)-3173
Resource Type:
Technical Report
Resource Relation:
Other Information: Orig. Receipt Date: 30-JUN-76
Country of Publication:
United States
Language:
English
Subject:
N48720* -Life Sciences-Nuclide Kinetics & Toxicology- Animals; 550500* -Biomedical Sciences, Basic Studies-Metabolism; *IODINE 131- TISSUE DISTRIBUTION; *IODINE- METABOLISM; *THYROID- RADIONUCLIDE KINETICS; BEAGLES; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL MODELS; DIET; DOGS; MAN; RESPONSE MODIFYING FACTORS; UPTAKE; VARIATIONS

Citation Formats

Becker, D.V., and Belshaw, B.E.. Effects of stable iodide blocking of exposure to radioiodine. Progress report, November 1, 1974--October 31, 1975. United States: N. p., 1975. Web. doi:10.2172/4153145.
Becker, D.V., & Belshaw, B.E.. Effects of stable iodide blocking of exposure to radioiodine. Progress report, November 1, 1974--October 31, 1975. United States. doi:10.2172/4153145.
Becker, D.V., and Belshaw, B.E.. Wed . "Effects of stable iodide blocking of exposure to radioiodine. Progress report, November 1, 1974--October 31, 1975". United States. doi:10.2172/4153145. https://www.osti.gov/servlets/purl/4153145.
@article{osti_4153145,
title = {Effects of stable iodide blocking of exposure to radioiodine. Progress report, November 1, 1974--October 31, 1975},
author = {Becker, D.V. and Belshaw, B.E.},
abstractNote = {Results are reported from studies on the influence of dietary iodine intake on the uptake of $sup 131$I by the thyroid gland of beagles. A model of iodine kinetics in normal dogs was developed that consists of separate subsystems for iodine, thyroxine, triiodothyronine, and the thyroid gland. The model demonstrates important differences in iodine metabolism and thyroid function between the dog and man. (CH)},
doi = {10.2172/4153145},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1975},
month = {Wed Jan 01 00:00:00 EST 1975}
}

Technical Report:

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  • In an effort to determine whether iodide administration in man can induce injury to thyroid follicular cells similar to that demonstrated in lower animals, this study measures thyroglobulin, thyroxine and triiodothyronine and thyroid autoantibodies in the serum before and after administration of iodine in a variety of patients. In the last eight months primary efforts have been devoted to the development of a high specificity and sensitivity radioimmunoassay of thyroglobulin and its preliminary clinical application. Human thyroglobulin obtained from operative specimens was purified and its identity and purity established. Rabbits were injected with thyroglobulin for 30 weeks with the appearancemore » of significant titres of antibodies within 6 weeks. The antibody developed was examined for immunological purity and used in a radioimmunoassay system with thyroglobulin labeled in this Laboratory with /sup 125/I.« less
  • In order to determine whether acute administration of iodide leads to any undesirable effects in the general population, we studied a group of patients who received iodinated radiographic contrast medium in the course of routine x-ray diagnostic procedures. We were particularly interested in investigating the possibility that administration of iodine could damage thyroid follicular cells leading to release of intrathyroidal antigens such as thyroglobulin into the blood. An increase in serum thyroglobulin might, in turn, either initiate or exacerbate thyroid autoimmunity in susceptible individuals, leading to autoimmune thyroiditis. We looked for undesirable effects due to the administration of iodide inmore » 3 ways: a possible acute toxic effect on thyroid follicular cells was investigated by determining serum thyroglobulin immediately prior to and 24 hours after injection of iodinated contrast medium; an effect on thyroid autoimmunity was investigated by determining thyroid autoantibodies immediately prior to and 3 to 6 months after injection of iodinated contrast medium; and acute and chronic effects on thyroid function were investigated by performing thyroid function tests immediately prior to, 24 hours after and 3 to 6 months after injection of iodinateed contrast medium.« less
  • A chain reaction may be formulated at alkaline pH in terms of e$sup -$/ sub aq/ acting as a source of $sup -$OH as a reactant and H. regenerating e$sup - $/sub aq/. This may account for radiolytic conversion of CO to formate with high G. $sup 60$Co $gamma$-radiolysis of alkaline aqueous acetonitrile and acetamide gave no evidence of a chain; extensive hydrolysis of methyl acetate is now attributed to non-radiolytic, normal hydrolysis. Aromatic mercaptans are found to retard photoreduction of a benzophenone by aliphatic amines, largely by hydrogen atom-transfer repair reactions. Aliphatic mercaptans accelerate photoreduction, apparently by affecting themore » reduction to quenching ratio in the intermediate charge-transfer complex. In photoreduction of a benzophenone by 2,3- butylene glycol at pH 3, the glycol is converted, not to 3-hydroxy-2-butanone, but to 2-butanone, and about 4 molecules of this are formed per molecule of ketone reduced. A short chain appears to be established. Mercaptan appears to accelerate the reduction of the ketone and retard the formation of 2-butanone. (auth)« less
  • Activities are described under the topics of education; publications and talks;research progress highlights; space and facilities; level of activity; and miscellaneous. Current research is reported for the high temperature thermodynamics and vaporization of the titanium oxides, the vaporization of the rare-earth borides, the phase studies on the Zr-Nb-O system, the studies on high- molecular weight inorganic species, and the kinetic studies on high-temperature vaporization processes. (auth)
  • The major effort in the high-energy nuclear chemistry program was the study of cross sections and kinematic properties of products formed from the interaction of 1- to 300-GeV protons with heavy- (Bi and U) and medium-mass (Cu, Ag) nuclei. The products studied ranged in mass from approximately 20 to that of the target nucleus. Except in the case of near-target product nuclei ($delta$A approximately 10 to 20), no substantial change in cross section or recoil properties was observed at 300 GeV from those measured at 11.5 GeV. New experiments are in progress to relate the production mechanisms of selected productsmore » to fundamental particle interactions and the production of exotic particles. Extensive preparations were made for another experiment to be performed soon at higher intensity on the search for polyneutron aggregates at the LAMPF Accelerator. Work is continuing on the use of stable isotope tracers (methane-20 and 21) for the study of long-range transport and diffusion phenomena in the atmosphere. A collaborative effort on the study of extraterrestrial objects (meteorites and lunar samples) is continuing. The work has involved correlations among trace and minor elements, the evolution of the lunar regolith, differentiation of lunar magmas, and a study of lunar agglutinates. (auth)« less