MODIFIED HOMOLOGOUS DISEASE FOLLOWING TRANSPLANTATION OF PARENTAL BONE MARROW AND RECIPIENT LIVER INTO IRRADIATED F$sub 1$ MICE
Bone marrow of C57BL donor mice incubated in vitro with (C57BL x 1Ol)F/ sub 1/ liver cells induced mortality in only 18% of lethally irradiated (C57BL x 101)F/sub 1/ recipients, whereas when incubated with C57BL liver cells or injected without preincubation, C57BL bone marrow killed 83 and 62%, respectively, of such recipients within 150 days. It is assumed that the mortality in lethally irradiated Fi recipipnts of parental bone marrow resulted from a graft-vs.-host immunological reaction. Therefore the reduction of mortality by preincubation of the bone marrow with recipient liver is attributed to depression of the immunological reactivity of the marrow. No explanation can bc given at the present time as to the mechanism by which the immunological reactivity of C57BL bone marrow may have been reduced; however, the phenomenon was recognized only when the liver cells were removed from the incubation mixtures before implantation, presumably because the F/sub 1/ liver contained immunologically competent cells that reacted against the parental bone marrow antigens. That donor hematopoietic elements survived the incubation in a functional state is indicated by their ability to protect and repopulate irradiatpd recipients and by the presence of donor type circulating prythrocytss in these animals. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-008575
- OSTI ID:
- 4109497
- Journal Information:
- Transplantation Bull., Vol. Vol: 27; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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