RE-UTILIZATION OF THYMIDINE DURING DEATH OF A CELL
Following large doses of x radiation, death of a murine ascites lymphoma cell occurred by a rapid intermitotic mechanism. The desoxyribonucleic acid (DNA) of these cells was labeled with tritiated thymidine, the cells killed by x- irradiation, and injected intravenously into recipient mice with growing ascites tumors. Tritium appeared in the DNA of the tumor and bone marrow cells of the recipient mice, with all the radioactivity present as thymine. This indicated a salvage and conservation mechanism for these molecules. (M.C.G.)
- Research Organization:
- Stanford Univ., Palo Alto, Calif.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-011601
- OSTI ID:
- 4107637
- Journal Information:
- Nature, Vol. Vol: 201; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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