Metabolism of linolenic acid in developing brain. I. Incorporation of radioactivity from 1-$sup 14$C linolenate into brain fatty acids

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Lipids, v. 10, no. 4, pp. 238-241

OSTI ID:4102009

Dhopeshwarkar, G A; Subramanian, C

Twelve-thirteen day old rats were given 1-$sup 14$C linolenic acid by intraperitoneal injection. Fatty acids were isolated from the brains of animals sacrificed at the end of 8 and 48 hr and 15 and 45 days. Eight hr after the tracer, radioactivity was found neither in 18:3 nor its end-product, 22:6, and palmitate was the most highly radioactive component. At longer intervals, 22:6 seemed to retain much of the radioactivity, whereas palmitate showed a precipitous decline in radioactivity. Initial oxidation of linolenate and sparing of the linolenate complexed with polar lipids are discussed. (auth)

• Research Organization: Univ. of California, Los Angeles
• NSA Number: NSA-33-015117
• OSTI ID: 4102009
• Journal Information: Lipids, v. 10, no. 4, pp. 238-241, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48830* -Life Sciences-New Tracer Techniques-Other
550601* -Biomedical Sciences
Basic Studies-Medicine- Unsealed Radionuclides in Diagnostics
*BRAIN- BIOCHEMICAL REACTION KINETICS
*CARBOXYLIC ACIDS- BIOCHEMICAL REACTION KINETICS
*LINOLENIC ACID- METABOLISM
CARBON 14
RATS
TRACER TECHNIQUES