MODIFICATION OF IRRADIATION EFFECTS IN THE PIGEON, COLUMBA LIVIA. II. EFFECTS OF DELAYED BONE MARROW IMPLANTATION
Delayed bone marrow transplantation, in contrast to immediate transplantation, resulted in an increased average survival time of approximately 20 days for both homologous and heterologous marrow in lethally irradiated pigeons. Delayed homotransplantation resulted in only partial repopulation by donor derived erythrocytes. Chimera reversal occurred or the proportion of donor erythrocytes in circulation reached a maximum and then declined, while immediate homotransplantations resulted in evental total repopulation by donor erythrocytes. In the heterologously treated pigeons in vivo agglutination occurred between the 4th and 6th day after heterotrans plantation regardless of the number of days after irradiation. Delayed heterotransplantation did not result in elimination of all the host's erythrocytes, as was the case for the immediate heterotransplants. However, hostspecies-specific hemagglutinins were detectable at titers ranging from 8 to 64 with host cells, and sufficiently potent to produce in vivo agglutination. The host-species-specific hemagglutinins, which were present in the delayed heterotransplants, disappeared 15 to 20 days after the marrow implant and by the 30th day donor-species-specific hemagglutinins appeared in the circulation. In contrast, the hostspecies-specific hennagglutinins persisted until death in the immediate heterotransplants. Chimera reversal occurred in all 5 of the delayed heterotransplants which survived until the 45th day postirradiation. In contrast, the longest surwival time after immediate heterotramsplantation was 19 days and total repopulation by donor erythrocytes occurred in all animals which survived 10 days or longer. (auth)
- Research Organization:
- Univ. of Wisconsin, Madison
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-023341
- OSTI ID:
- 4058197
- Journal Information:
- Proc. Soc. Exptl. Biol. Med., Vol. Vol: 107; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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