Total-body irradiation and human chromosomes. V. Additional evidence of a transferable substance in the plasma of irradiated persons to induce chromosomal breakages

Journal Article · Wed Jan 01 00:00:00 EST 1975 · J. Med. (Westbury, N.Y.), v. 6, no. 1, pp. 51-60

OSTI ID:4039604

Goh, K

A substance (or substances) produced or activated by total-body irradiation in man and capable of affecting the chromosomes for an extended time has been postulated. Leukocytes from normal persons were cultured with autologous plasma, homologous plasma or serum from patients irradiated 10.5 years previously. Thirty (5.5 percent) chromosomal breaks were found in the 550 metaphases from the control cultures, 152 (13 percent) in the 1175 metaphases from the irradiated plasma cultures and 130 (12 percent) in the 1100 metaphases from the irradiated serum cultures. This finding confirms and extends our previous observation that plasma from total-body irradiated persons is capable of inducing chromosomal breakage in normal leukocytes even 10.5 years after the irradiation. (auth)

• Research Organization: Oak Ridge Associated Universities, TN
• NSA Number: NSA-33-029629
• OSTI ID: 4039604
• Journal Information: J. Med. (Westbury, N.Y.), v. 6, no. 1, pp. 51-60, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48510* -Life Sciences-Radiation Effects on Animals-Man
560151* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Man
*CHROMOSOMAL ABERRATIONS- RADIOINDUCTION
*IONIZING RADIATIONS- ABSCOPAL RADIATION EFFECTS
*LEUKOCYTES- BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
MAN
WHOLE-BODY IRRADIATION