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Title: THE BIOLOGICAL EFFECTS OF STRESSFUL AGENTS AS RELATED TO DIET

Abstract

Urease is produced by plants, fungi, and 200 species of bacteria. Urease producing bacteria were found to be resistant to antibiotics. The emzyme was found to be produced by bacteria which are normally found in the gastrointestimal tract of man and animals. Urease pro duces ammonia thrcugh urea hydrolysis. The substrate, urea, is constantly produced by mammalian tissues and is carried by tissue fluid and other secretions to the area where the enzyme is active. Ammonia, a known toxin produced by this process, is detoxified in the liver by reconversion to urea. In the case of birds or certhin mammals which prcduce uric acid, this substance was found to be decomposed to urea by bacteria and to serve indirectly as a substrate for urease. Inhibition of urea breakdown by this process produced growth increases of 10 to 40% in experiments with rats and chickens. Inhibition of urease activity followed the addition of antibacterial agents tc the diet, and good results were obthined with pericillin, chlortetracycline, and arsanilic acid. These inhibited the formation of urease by bacteria of the intestinal tract in both in vitro and in vivo studies and also appeared to alter bacterial growth under certain circumstances. Immunity tomore » jackbean urease resulted in the passage of antiurease into the gastrointestinal and urinary tracts, thereby inhibiting the formation of bacterial enzymes in rats and chickens. A highly sensitive and reliable hemagglutination techrique was developed for the detection of antiurease. Antiurease was not found in the sera of normal birds, laboratory animals, or man. Preliminary screening of sera from hospital patients indicates that the antibody may be significant in patients with certhin diseases. A list is included of papers published and abstracts are included of papers presented at scientific meetings during the period covered. (C.H.)« less

Authors:
Publication Date:
Research Org.:
Chicago. Univ.
OSTI Identifier:
4037873
Report Number(s):
TID-12906
NSA Number:
NSA-15-023198
DOE Contract Number:  
AT(11-1)-670
Resource Type:
Technical Report
Resource Relation:
Other Information: Orig. Receipt Date: 31-DEC-61
Country of Publication:
United States
Language:
English
Subject:
BIOLOGY AND MEDICINE; AMINES; AMMONIA; ANIMALS; ANTIBIOTICS; ARSANILIC ACID; ARSENIC COMPOUNDS; ARSONIC ACID; BACTERIA; BIOLOGY; BIRDS; BLOOD SERUM; DECOMPOSITION; DIET; DRUGS; ENZYMES; FUNGI; HETEROCYCLICS; IMMUNITY; INTESTINE; LIVER; MAN; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PENICILLIN; PLANTS; PURINES; RATS; STOMACH; STRESSES; TETRACYCLINES; TISSUES; UREA; UREASE; URIC ACID

Citation Formats

Visek, W J. THE BIOLOGICAL EFFECTS OF STRESSFUL AGENTS AS RELATED TO DIET. United States: N. p., 1961. Web.
Visek, W J. THE BIOLOGICAL EFFECTS OF STRESSFUL AGENTS AS RELATED TO DIET. United States.
Visek, W J. 1961. "THE BIOLOGICAL EFFECTS OF STRESSFUL AGENTS AS RELATED TO DIET". United States.
@article{osti_4037873,
title = {THE BIOLOGICAL EFFECTS OF STRESSFUL AGENTS AS RELATED TO DIET},
author = {Visek, W J},
abstractNote = {Urease is produced by plants, fungi, and 200 species of bacteria. Urease producing bacteria were found to be resistant to antibiotics. The emzyme was found to be produced by bacteria which are normally found in the gastrointestimal tract of man and animals. Urease pro duces ammonia thrcugh urea hydrolysis. The substrate, urea, is constantly produced by mammalian tissues and is carried by tissue fluid and other secretions to the area where the enzyme is active. Ammonia, a known toxin produced by this process, is detoxified in the liver by reconversion to urea. In the case of birds or certhin mammals which prcduce uric acid, this substance was found to be decomposed to urea by bacteria and to serve indirectly as a substrate for urease. Inhibition of urea breakdown by this process produced growth increases of 10 to 40% in experiments with rats and chickens. Inhibition of urease activity followed the addition of antibacterial agents tc the diet, and good results were obthined with pericillin, chlortetracycline, and arsanilic acid. These inhibited the formation of urease by bacteria of the intestinal tract in both in vitro and in vivo studies and also appeared to alter bacterial growth under certain circumstances. Immunity to jackbean urease resulted in the passage of antiurease into the gastrointestinal and urinary tracts, thereby inhibiting the formation of bacterial enzymes in rats and chickens. A highly sensitive and reliable hemagglutination techrique was developed for the detection of antiurease. Antiurease was not found in the sera of normal birds, laboratory animals, or man. Preliminary screening of sera from hospital patients indicates that the antibody may be significant in patients with certhin diseases. A list is included of papers published and abstracts are included of papers presented at scientific meetings during the period covered. (C.H.)},
doi = {},
url = {https://www.osti.gov/biblio/4037873}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1961},
month = {6}
}

Technical Report:
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