skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biosensor-based detection and verification system for bio-chemical warfare agents. Final report, 9 June 1991-9 June 1996

Abstract

The purpose of this contract was to explore and demonstrate the application of technology based on the Light Addressable Potentiometric Sensor (LAPS) to detection and verification problems for bio-chemical warfare agents. The principal analytical method employed was microphysiometry, by which perturbations of cell physiology are detected using the LAPS. The work was done in three principal segments. First, silicon microtechnology was used to design and fabricate sensor chips and microfluidic components suitable for the project. Second, a systems-engineering effort designed and assembled a prototype high-performance microphysiometer. Third, a biological effort employed a wide variety of cellular and ligand-receptor model systems to validate the generality of the method and the performance of the prototype instrument.

Authors:
Publication Date:
Research Org.:
Molecular Devices Corp., Sunnyvale, CA (United States)
OSTI Identifier:
402062
Report Number(s):
AD-A-311313/1/XAB; DA-9196
CNN: Contract MDA72-92-C-0005, ARPA ORDER-8143; TRN: 63020191
Resource Type:
Technical Report
Resource Relation:
Other Information: DN: See also ADA311312; PBD: 8 Jul 1996
Country of Publication:
United States
Language:
English
Subject:
35 ARMS CONTROL; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; BIOLOGICAL WARFARE AGENTS; VERIFICATION; DETECTION; CHEMICAL WARFARE AGENTS; POTENTIOMETERS; TECHNOLOGY ASSESSMENT; BIOCHEMISTRY; PROGRESS REPORT

Citation Formats

Owicki, J C. Biosensor-based detection and verification system for bio-chemical warfare agents. Final report, 9 June 1991-9 June 1996. United States: N. p., 1996. Web.
Owicki, J C. Biosensor-based detection and verification system for bio-chemical warfare agents. Final report, 9 June 1991-9 June 1996. United States.
Owicki, J C. Mon . "Biosensor-based detection and verification system for bio-chemical warfare agents. Final report, 9 June 1991-9 June 1996". United States.
@article{osti_402062,
title = {Biosensor-based detection and verification system for bio-chemical warfare agents. Final report, 9 June 1991-9 June 1996},
author = {Owicki, J C},
abstractNote = {The purpose of this contract was to explore and demonstrate the application of technology based on the Light Addressable Potentiometric Sensor (LAPS) to detection and verification problems for bio-chemical warfare agents. The principal analytical method employed was microphysiometry, by which perturbations of cell physiology are detected using the LAPS. The work was done in three principal segments. First, silicon microtechnology was used to design and fabricate sensor chips and microfluidic components suitable for the project. Second, a systems-engineering effort designed and assembled a prototype high-performance microphysiometer. Third, a biological effort employed a wide variety of cellular and ligand-receptor model systems to validate the generality of the method and the performance of the prototype instrument.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {7}
}

Technical Report:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that may hold this item. Keep in mind that many technical reports are not cataloged in WorldCat.

Save / Share: