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Title: LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION

Abstract

An investigation of the lipids of the mitochondrial membrane from rat liver indicates that the mole % lipid composition of the membrane is cephalin 55%, lecithin 34%, cholesterol 3%, and glycerides 8%. The phosphatides are phosphatidyl choline, phosphatidyl ethanolamine, and a small amount of phosphatidyl serine. The fatty acid composition of the membrane phospholipids were determined by gas chromatography. Evidence in the literature indicates that liver mitochondria are damaged as a result of whole-body irradiation. Data obtained in the present study show that irradiation does not cause a loss of any of the major classes of lipids from the mitochondrial membrane during the first 40 minutes following 1000 r whole-body x irradiation. Because x irradiation is known to destroy unsaturated fatty acids, it is of interest that there was no loss of unsaturated fatty acids from the membrane phospholipids. Rather, irradiation caused an increase in the amounts of the unsaturated fatty acids, linoleic and arachidonic acid, in the phosphatidyl choline fraction of the membrane. It is clear that whatever the mechanism is, whereby liver mitochondria are altered during an early period following irradiation, it does not involve major destruction of lipids in the mitochondrial membrane. (auth)

Authors:
;
Publication Date:
Research Org.:
Naval Radiological Defense Lab., San Francisco
OSTI Identifier:
4018709
Report Number(s):
USNRDL-TR-504
NSA Number:
NSA-15-017933
Resource Type:
Technical Report
Resource Relation:
Other Information: Orig. Receipt Date: 31-DEC-61
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; AMINES; ARACHIDONIC ACID; BODY; IRRADIATION; LINOLEIC ACID; LIPIDS; LIVER; MEMBRANES; MITOCHONDRIA; ORGANIC ACIDS; RADIATION EFFECTS; RADIATION INJURIES; RATS; WHOLE-BODY IRRADIATION; X RADIATION

Citation Formats

Jackson, K L, and Entenman, C. LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION. Country unknown/Code not available: N. p., 1961. Web.
Jackson, K L, & Entenman, C. LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION. Country unknown/Code not available.
Jackson, K L, and Entenman, C. Tue . "LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION". Country unknown/Code not available.
@article{osti_4018709,
title = {LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION},
author = {Jackson, K L and Entenman, C},
abstractNote = {An investigation of the lipids of the mitochondrial membrane from rat liver indicates that the mole % lipid composition of the membrane is cephalin 55%, lecithin 34%, cholesterol 3%, and glycerides 8%. The phosphatides are phosphatidyl choline, phosphatidyl ethanolamine, and a small amount of phosphatidyl serine. The fatty acid composition of the membrane phospholipids were determined by gas chromatography. Evidence in the literature indicates that liver mitochondria are damaged as a result of whole-body irradiation. Data obtained in the present study show that irradiation does not cause a loss of any of the major classes of lipids from the mitochondrial membrane during the first 40 minutes following 1000 r whole-body x irradiation. Because x irradiation is known to destroy unsaturated fatty acids, it is of interest that there was no loss of unsaturated fatty acids from the membrane phospholipids. Rather, irradiation caused an increase in the amounts of the unsaturated fatty acids, linoleic and arachidonic acid, in the phosphatidyl choline fraction of the membrane. It is clear that whatever the mechanism is, whereby liver mitochondria are altered during an early period following irradiation, it does not involve major destruction of lipids in the mitochondrial membrane. (auth)},
doi = {},
journal = {},
number = ,
volume = ,
place = {Country unknown/Code not available},
year = {1961},
month = {4}
}

Technical Report:
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