Laser-polarized {sup 129}Xe: A new direction for in vivo magnetic resonance imaging and spectroscopy
While the recent demonstrations of in vivo magnetic resonance imaging using laser-polarized {sup 3}He are impressive, there is great interest in utilizing the technique for {sup 129}Xe. The high solubility of {sup 129}Xe in tissue (10-20mM) and the large chemical shift separation between gas and solution environments (200 ppm) make spectroscopic differentiation of gas phase and tissue compartments facile. To understand the physicological and magnetic behavior of {sup 129}Xe, for imaging, the authors have obtained MR spectra from the mouse thorax in vivo using laser-polarized {sup 129}Xe. These show many peaks and much detail: (1) Alveolar gas phase {sup 129}Xe shows intensity and frequency fluctuations correlated with breathing-induced variations in bulk magnetic susceptibility (BMS) of the lung. (2) {sup 129}Xe dissolved in the lung parenchyma also shows BMS correlated variation as well as very rapid T{sub 2} relaxation (< 20ms), attributable to BMS broadening and respiratory motion. (3) Blood and thoracic muscle components are easily distinguished by their different frequencies and intensity buildup rates. These show T{sub 2} times of 60 and 80 ms, respectively. (4) Effective T{sub 1} relaxation times, (including {sup 129}Xe washout) are long in all tissue environments, about 25-30 s. The authors will discuss these results as well as advances toward systems capable of producing large quantities of laser-polarized {sup 129}Xe.
- OSTI ID:
- 394182
- Report Number(s):
- CONF-9605105-; ISSN 0003-0503; TRN: 96:005793-0085
- Journal Information:
- Bulletin of the American Physical Society, Vol. 41, Issue 3; Conference: 27. annual meeting of the Division of Atomic, Molecular and Optical Physics (DAMOP) of the American Physical Society (APS), Ann Arbor, MI (United States), 15-18 May 1996; Other Information: PBD: May 1996
- Country of Publication:
- United States
- Language:
- English
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