Allelic association at the D14S43 locus in early onset Alzheimer`s disease
- and others
The D14S43 marker is closely linked to the major gene for early onset autosomal dominant Alzheimer`s disease on chromosome 14. Allelic frequencies at the D14S43 locus were compared in 113 familial and isolated cases of early onset Alzheimer`s disease (<60 years of age at onset) (EOAD) and 109 unaffected individuals of the same geographic origin. Allele 7 was significantly (P = 0.033) more frequent in type 1 EOAD patients (13.2%), defined by the presence of at least another first degree relative with EOAD, than in controls (4.1%). Since an autosomal dominant gene is probably responsible for type 1 patients, allelic association may reflect linkage disequilibrium at the D14S43 locus. This would mean that some patients share a common ancestral mutation. However, since multiple tests were carried out, this result must be interpreted with caution, and needs confirmation in an independent sample. 16 refs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 393888
- Journal Information:
- American Journal of Medical Genetics, Vol. 60, Issue 2; Other Information: PBD: 24 Apr 1995
- Country of Publication:
- United States
- Language:
- English
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