An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes

Journal Article · Fri Dec 01 00:00:00 EST 1995 · Molecular and Cellular Biology

DOI:https://doi.org/10.1128/MCB.15.12.6961· OSTI ID:379278

Zhang, Liqun; Teng, Yen-Tung; Melet, F ^[1]

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1. Univ. of Toronto, Ontario (Canada); and others

This report describes how expression of the proto-oncogene Fli-1 is involved in the regulation of lymphopoiesis. Transgenic mice were generated which overexpressed the oncogene, leading to a high incidence of immunological renal diseases and death. The data suggests that overexpression of Fli-1 perturbs normal lymphoid cell function and programmed cell death, making these transgenic mice suitable as a biological model for autoimmune disease in humans. 35 refs., 6 figs., 4 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 379278
• Journal Information: Molecular and Cellular Biology, Vol. 15, Issue 12; Other Information: PBD: Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
TRANSGENIC MICE
UROGENITAL SYSTEM DISEASES
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
PATHOGENESIS
ONCOGENES
GENE REGULATION
TISSUE DISTRIBUTION
GENE MUTATIONS
TRANSCRIPTION FACTORS
CHROMOSOMES
CHROMOSOMAL ABERRATIONS
ANIMAL CELLS
GROWTH
CELL PROLIFERATION
BIOLOGICAL MODELS