Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
Journal Article
·
· Molecular and Cellular Biology
- Univ. of Texas Health Science Center, San Antonio, TX (United States)
The p53 tumor suppressor protein negatively regulates cell growth and somatic mutations in the p53 gene lead to uncontrolled cell growth and oncogenesis. This report describes research which demonstrates, using a number of different cell lines, that at low levels, wild-type p53 transactivates the human proliferating cell nuclear antigen (PCNA) promoter. When expressed at similar levels, tumor-derived p53 mutants did not transactivate the PCNA promoter. It also reports the identification of a wild-type human p53-binding site on the human PCNA promote. 84 refs., 5 figs, 3 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 379263
- Journal Information:
- Molecular and Cellular Biology, Vol. 15, Issue 12; Other Information: PBD: Dec 1995
- Country of Publication:
- United States
- Language:
- English
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