U.S. Department of EnergyOffice of Scientific and Technical Information
Self-assembling multimeric nucleic acid constructs
Abstract
The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products. 5 figs.
- Inventors:
- Publication Date:
- Research Org.:
- Boston University
- OSTI Identifier:
- 378135
- Patent Number(s):
- US 5,561,043/A/
- Application Number:
- PAN: 8-189,448
- Assignee:
- Boston Univ., MA (United States)
- DOE Contract Number:
- FG02-93ER61656
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 1 Oct 1996
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; NUCLEIC ACIDS; MOLECULAR BIOLOGY; CHEMICAL COMPOSITION; USES; SPECIFICITY
Citation Formats
Cantor, C R, Niemeyer, C M, Smith, C L, Sano, Takeshi, Hnatowich, D J, and Rusckowski, M. Self-assembling multimeric nucleic acid constructs. United States: N. p., 1996.
Web.
Cantor, C R, Niemeyer, C M, Smith, C L, Sano, Takeshi, Hnatowich, D J, & Rusckowski, M. Self-assembling multimeric nucleic acid constructs. United States.
Cantor, C R, Niemeyer, C M, Smith, C L, Sano, Takeshi, Hnatowich, D J, and Rusckowski, M. 1996.
"Self-assembling multimeric nucleic acid constructs". United States.
@article{osti_378135,
title = {Self-assembling multimeric nucleic acid constructs},
author = {Cantor, C R and Niemeyer, C M and Smith, C L and Sano, Takeshi and Hnatowich, D J and Rusckowski, M},
abstractNote = {The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products. 5 figs.},
doi = {},
url = {https://www.osti.gov/biblio/378135},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 1996},
month = {Tue Oct 01 00:00:00 EDT 1996}
}